Technology Process of 5-AMino-6-Methyl-2,1,3-benzothiadiazole
There total 4 articles about 5-AMino-6-Methyl-2,1,3-benzothiadiazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methyl-5-nitrobenzene-1,2-diamine;
With
thionyl chloride; triethylamine; sodium hydroxide;
In
dichloromethane;
at 20 ℃;
for 5h;
Inert atmosphere;
With
hydrogenchloride; tin(ll) chloride;
In
water;
at 20 ℃;
for 2h;
DOI:10.1016/j.bmc.2015.11.035
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid; nitric acid / 4 h / 2 - 20 °C / Inert atmosphere
1.2: 4 h / 80 °C / Inert atmosphere
2.1: sodium sulfide; water / ethanol / 2 h / 20 - 100 °C / Inert atmosphere
3.1: sodium hydroxide; thionyl chloride; triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C
With
sodium sulfide; thionyl chloride; sulfuric acid; water; nitric acid; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane;
DOI:10.1016/j.bmc.2015.11.035
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium sulfide; water / ethanol / 2 h / 20 - 100 °C / Inert atmosphere
2.1: sodium hydroxide; thionyl chloride; triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere
2.2: 2 h / 20 °C
With
sodium sulfide; thionyl chloride; water; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane;
DOI:10.1016/j.bmc.2015.11.035
