2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine

Base Information

• Chemical Name: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine
• CAS No.: 1223020-29-8
• Molecular Formula: C₄₉H₄₅N₅
• Molecular Weight: 703.93
• Mol file: 1223020-29-8.mol

Synonyms:2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine;PyBidine;2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine

Chemical Property of 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine

Chemical Property:

• PKA: 7.02±0.70(Predicted)
• PSA: 43.43000
• Density: 1.178±0.06 g/cm3(Predicted)
• LogP: 10.78820
• Storage Temp.: <0°C

Purity/Quality:

98% ^*data from raw suppliers

2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine (CAS# 1223020-29-8) is a versatile organic catalyst used in a variety of reactions such as asymmetric Friedel-Crafts reactions, and the preparation of chiral quaternary N,O-acetals.

Technology Process of 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine

There total 1 articles about 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Pyridinedicarboxaldehyde (5431-44-7) + (1S,2S)-N1-benzyl-1,2-diphenylethane-1,2-diamine (1207290-26-3) → 2,6-bis((2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl)pyridine (1223020-29-8)

Guidance literature:

With acetic acid; In dichloromethane; at 20 - 30 ℃; Inert atmosphere;

DOI:10.1021/ja100265j

Reference yield:

2,6-bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine (1223020-29-8) + nickel dichloride (83864-14-6) → C49H45ClN5Ni(1+)*Cl(1-)

Guidance literature:

In dichloromethane; for 6h; Inert atmosphere;

DOI:10.1021/ol501085y DOI:10.1021/acs.orglett.5b00928

Reference yield:

2,6-bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine (1223020-29-8) + nickel(II) acetate tetrahydrate (6018-89-9) → 2C2H3O2(1-)*Ni(2+)*C49H45N5

Guidance literature:

In methanol; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02783

upstream raw materials:

2,6-Pyridinedicarboxaldehyde

(1S,2S)-N₁-benzyl-1,2-diphenylethane-1,2-diamine

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