Ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate
CAS No.:228728-82-3
Molecular Formula:C12H9F2NO3
Molecular Weight:253.2015664
Hs Code.:2933499090
DSSTox Substance ID:DTXSID20395561
Wikidata:Q82195707
Mol file:228728-82-3.mol

Synonyms:ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate;228728-82-3;ethyl 5,7-difluoro-4-oxo-1H-quinoline-3-carboxylate;Oprea1_205903;SCHEMBL6201539;DTXSID20395561;HMS1659H15;BBL028334;MFCD00173415;STK787826;AKOS000271165;SB69546;BB 0222266;CS-0313040;6J-068;ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate;F3173-0034;5,7-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester;Ethyl 5,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate;5,7-Difluoro-4-hydroxy-quinoline-3-carboxylic acid ethyl ester

Suppliers and Price of Ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate 97%
5g
$ 485.00

Crysdot
Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate 97%
10g
$ 703.00

Chemenu
Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate 97%
10g
$ 664.00

Chemenu
Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate 97%
5g
$ 458.00

Apolloscientific
Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate
1g
$ 312.00

Apolloscientific
Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate
250mg
$ 102.00

Total 4 raw suppliers

Chemical Property of Ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:9.99E-05mmHg at 25°C
Melting Point:313 °C (ethanol)
Boiling Point:338.2°C at 760 mmHg
Flash Point:158.3°C
PSA：59.16000
Density:1.386g/cm³
LogP:1.98300
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:253.05504947
Heavy Atom Count:18
Complexity:397

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5,7-difluoro-4-hydroxyquinoline-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CNC2=C(C1=O)C(=CC(=C2)F)F

Technology Process of Ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate

There total 5 articles about Ethyl 5,7-difluoro-4-hydroxyquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 372-39-4
3,5-difluoroaniline

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 185011-62-5,228728-82-3
ethyl 5,7-difluoro-4(1H)-quinolone-3-carboxylate

Guidance literature:: 3,5-difluoroaniline; diethyl 2-ethoxymethylenemalonate; In neat (no solvent); at 120 ℃; for 1h; Inert atmosphere;

With Eaton′s Reagent; In neat (no solvent); at 130 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejic.201901036

Reference yield: 61.0%

: 185010-69-9
2-[(3,5-Difluoro-phenylamino)-methylene]-malonic acid diethyl ester

: 185011-62-5,228728-82-3
ethyl 5,7-difluoro-4(1H)-quinolone-3-carboxylate

Guidance literature:: In diphenylether; at 250 ℃; for 3h;

Reference yield:

: 372-39-4
3,5-difluoroaniline

: 185011-62-5,228728-82-3
ethyl 5,7-difluoro-4(1H)-quinolone-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 115 - 120 °C / 30-60 min

2: Dowtherm A / 1 h / 250 °C

With diphenyl ether-biphenyl eutectic;
DOI:10.1002/(SICI)1097-458X(199611)34:11<972::AID-OMR994>3.0.CO;2-9