Methyl 2-amino-4-chloro-5-methoxybenzoate

Base Information

• Chemical Name: Methyl 2-amino-4-chloro-5-methoxybenzoate
• CAS No.: 181434-36-6
• Molecular Weight: 215.63
• European Community (EC) Number: 874-604-5
• Mol file: 181434-36-6.mol

Synonyms:methyl 2-amino-4-chloro-5-methoxybenzoate;181434-36-6;SCHEMBL7842075;AQLRQXBTXPAANE-UHFFFAOYSA-N;MFCD24638645;AKOS024218335;SB79405;AS-41178;DA-33042;methyl2-amino-4-chloro-5-methoxybenzoate;CS-0102740;EN300-7396857

Chemical Property of Methyl 2-amino-4-chloro-5-methoxybenzoate

Chemical Property:

• Boiling Point: 328.9±37.0 °C(Predicted)
• PKA: 1.84±0.10(Predicted)
• Density: 1.302±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 215.0349209
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-amino-4-chloro-5-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)C(=O)OC)N)Cl

Technology Process of Methyl 2-amino-4-chloro-5-methoxybenzoate

There total 2 articles about Methyl 2-amino-4-chloro-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methanol (67-56-1) + 2-tert-butoxycarbonylamino-4-chloro-5-methoxy-benzoic acid (1616295-97-6) → methyl 2-Amino-4-chloro-5-methoxybenzoate (181434-36-6)

Guidance literature:

With thionyl chloride; Reflux;

Reference yield: 46.0%

2-amino-4-chloro-5-methoxy-benzoic acid (181434-76-4) → methyl 2-Amino-4-chloro-5-methoxybenzoate (181434-36-6)

Guidance literature:

In methanol;

upstream raw materials:

2-amino-4-chloro-5-methoxy-benzoic acid

methanol

2-tert-butoxycarbonylamino-4-chloro-5-methoxy-benzoic acid