(Pyridin-2-ylmethyl)(pyridin-3-ylmethyl)amine

Base Information

• Chemical Name: (Pyridin-2-ylmethyl)(pyridin-3-ylmethyl)amine
• CAS No.: 128802-95-9
• Molecular Formula: C12H13N3
• Molecular Weight: 199.25
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID101259950
• Mol file: 128802-95-9.mol

Synonyms:(Pyridin-2-ylmethyl)(pyridin-3-ylmethyl)amine;128802-95-9;1-(Pyridin-2-yl)-N-(pyridin-3-ylmethyl)methanamine;1-pyridin-3-yl-N-(pyridin-2-ylmethyl)methanamine;picolyl(3 picolyl)amine;SCHEMBL8805346;DTXSID101259950;MFCD02656617;AKOS000243971;PS-5469;SB52733;BB 0220063;CS-0444256;N-(3-Pyridinylmethyl)-2-pyridinemethanamine;[(pyridin-2-yl)methyl][(pyridin-3-yl)methyl]amine

Chemical Property of (Pyridin-2-ylmethyl)(pyridin-3-ylmethyl)amine

Chemical Property:

• PSA: 37.81000
• LogP: 2.15730
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 199.110947427
• Heavy Atom Count: 15
• Complexity: 172

Purity/Quality:

98%min ^*data from raw suppliers

1-(Pyridin-2-yl)-N-[(pyridin-3-yl)methyl]methylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CNCC2=CN=CC=C2

Technology Process of (Pyridin-2-ylmethyl)(pyridin-3-ylmethyl)amine

There total 3 articles about (Pyridin-2-ylmethyl)(pyridin-3-ylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(E)-N-(pyridin-2-ylmethylene)-1-(pyridin-3-yl)methanamine → 1-(pyridine-2-yl)-N-(pyridin-3-ylmethyl)methanamine (128802-95-9)

Guidance literature:

(E)-N-(pyridin-2-ylmethylene)-1-(pyridin-3-yl)methanamine; With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h;

With sodium chloride; In methanol; for 5h; Reflux;

DOI:10.1016/j.poly.2014.12.036

Reference yield: 52.2%

pyridine-2-carbaldehyde (1121-60-4) + 3-Aminomethylpyridine (3731-52-0) → 1-(pyridine-2-yl)-N-(pyridin-3-ylmethyl)methanamine (128802-95-9)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In methanol;

DOI:10.1039/c3dt33024a

Reference yield:

pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) → 1-(pyridine-2-yl)-N-(pyridin-3-ylmethyl)methanamine (128802-95-9)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; water; hydrogen; silica gel; 2,2′‐biquinoline‐4,4′‐dicarboxylic acid dipotassium salt; In hexane; at 100 ℃; for 24h; under 10343.2 Torr; chemoselective reaction; Autoclave; Green chemistry;

DOI:10.1002/aoc.4547

upstream raw materials:

pyridine-2-carbaldehyde

3-Aminomethylpyridine

pyridine-3-carbonitrile

Refernces

• 1、 Nait Ajjou, Abdelaziz,Robichaud, André. "Chemoselective hydrogenation of nitriles to secondary or tertiary amines catalyzed by aqueous-phase catalysts supported on hexagonal mesoporous silica". . . Retrieved 2018/09/12.