3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE

Base Information

• Chemical Name: 3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE
• CAS No.: 856834-95-2
• Molecular Formula: C6H4BrClN2O2
• Molecular Weight: 251.467
• Hs Code.: 2933399090
• Mol file: 856834-95-2.mol

Synonyms:3-Bromo-2-chloro-6-methyl-5-nitropyridine;5-Bromo-6-chloro-3-nitro-2-picoline;

Chemical Property of 3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE

Chemical Property:

• Melting Point: 93℃
• Boiling Point: 296℃
• PKA: -4.03±0.10(Predicted)
• Flash Point: 133℃
• PSA: 58.71000
• Density: 1.810
• LogP: 3.23730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

3-Bromo-2-chloro-5-nitro-6-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE

There total 9 articles about 3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

3-bromo-6-methyl-5-nitro-pyridin-2-ol (874493-25-1) → 3-bromo-2-chloro-6-methyl-5-nitropyridine (856834-95-2)

Guidance literature:

With trichlorophosphate; at 80 ℃;

Reference yield:

α-picoline (109-06-8) → 3-bromo-2-chloro-6-methyl-5-nitropyridine (856834-95-2)

Guidance literature:

Multi-step reaction with 4 steps

1: liquid NH₃; xylene; Fe(NO₃)3

2: concentrated H₂SO₄; concentrated HNO₃

3: acetic acid; bromine

4: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization

With hydrogenchloride; sulfuric acid; ammonia; bromine; nitric acid; acetic acid; ferric nitrate; xylene; sodium nitrite;

DOI:10.1021/ja01193a016

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 3-bromo-2-chloro-6-methyl-5-nitropyridine (856834-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: concentrated H₂SO₄; concentrated HNO₃

2: acetic acid; bromine

3: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization

With hydrogenchloride; sulfuric acid; bromine; nitric acid; acetic acid; sodium nitrite;

DOI:10.1021/ja01193a016

upstream raw materials:

2-amino-3-bromo-6-methyl-5-nitropyridine

α-picoline

2-Amino-6-methylpyridine

6-methyl-5-nitro-2-pyridinamine

Downstream raw materials:

3-bromo-2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitropyridine

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". Paragraph 1925; 1926. . Retrieved 2018/07/05.
• 2、 -. "INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1". Paragraph 00275; 00276. . Retrieved 2015/06/25.