(S)- alpha-amino-1,3-Benzodioxole-5-acetic acid

Base Information

• Chemical Name: (S)- alpha-amino-1,3-Benzodioxole-5-acetic acid
• CAS No.: 250666-02-5
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.17206
• Mol file: 250666-02-5.mol

Synonyms:(S)- alpha-amino-1,3-Benzodioxole-5-acetic acid;L-3,4-Methylenedioxyphenylglycine

Chemical Property of (S)- alpha-amino-1,3-Benzodioxole-5-acetic acid

Chemical Property:

• PSA: 81.78000
• LogP: 1.20000

Purity/Quality:

98%min ^*data from raw suppliers

(S)-alpha-amino-1,3-Benzodioxole-5-aceticacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)- alpha-amino-1,3-Benzodioxole-5-acetic acid

There total 6 articles about (S)- alpha-amino-1,3-Benzodioxole-5-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[2S,1'S,2'S]-(+)-2-amino-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (250665-98-6) → (S)-(+)-3,4-(methylenedioxy)phenylglycine (250666-02-5)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; Heating;

DOI:10.1016/S0040-4039(99)01475-6

Reference yield: 41.0%

amino-(3,4-methylenedioxyphenyl)-acetonitrile (69810-87-3) → (S)-(+)-3,4-(methylenedioxy)phenylglycine (250666-02-5) + (S)-2-Amino-2-benzo[1,3]dioxol-5-yl-acetamide + D-(-)-3,4-methylenedioxyphenylglycine amide

Guidance literature:

With Rhodococcus sp. AJ₂₇₀; In phosphate buffer; at 30 ℃; for 2h; pH=7.62;

DOI:10.1016/S0040-4039(01)01439-3

Reference yield: 39.0%

amino-(3,4-methylenedioxyphenyl)-acetonitrile (69810-87-3) → (S)-(+)-3,4-(methylenedioxy)phenylglycine (250666-02-5) + D-(-)-3,4-methylenedioxyphenylglycine amide

Guidance literature:

With potassium phosphate buffer; Rhodococcus sp. AJ₂₇₀ cells; In water; at 30 ℃; for 2.2h; pH=7.62;

DOI:10.1021/jo0256282

upstream raw materials:

[2S,1'S,2'S]-(+)-2-amino-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide

amino-(3,4-methylenedioxyphenyl)-acetonitrile

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide

[2S,1'S,2'S]-(+)-2-[N,N'-bis(1,1-dimethylethoxycarbonyl)hydrazino]-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide

Downstream raw materials:

(S)-Benzo[1,3]dioxol-5-yl-[(2,3-dimethoxy-benzyl)-methyl-amino]-acetaldehyde

(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

(6R,7R)-7-((S)-2-Amino-2-benzo[1,3]dioxol-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(2S)-(-)-2-(2,3-dimethoxybenzyl)-N-methylamino-2-(3,4-methylenedioxyphenyl)ethanol