2,2-DIMETHYL-3'-METHOXYPROPIOPHENONE

Base Information

• Chemical Name: 2,2-DIMETHYL-3'-METHOXYPROPIOPHENONE
• CAS No.: 32578-12-4
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Hs Code.: 2914509090
• Mol file: 32578-12-4.mol

Synonyms:2,2-DIMETHYL-3'-METHOXYPROPIOPHENONE;(3-methoxyphenyl) tert-butyl ketone

Chemical Property of 2,2-DIMETHYL-3'-METHOXYPROPIOPHENONE

Chemical Property:

• Vapor Pressure: 0.00773mmHg at 25°C
• Boiling Point: 268.3°C at 760 mmHg
• Flash Point: 103.9°C
• PSA: 26.30000
• Density: 0.988g/cm³
• LogP: 2.92400

Purity/Quality:

99% ^*data from raw suppliers

1-(3-methoxyphenyl)-2,2-dimethylpropan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-3'-METHOXYPROPIOPHENONE

There total 6 articles about 2,2-DIMETHYL-3'-METHOXYPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-methoxy-benzaldehyde (591-31-1) + 1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate (84379-72-6) → 1-(3-methoxyphenyl)-2,2-dimethylpropan-1-one (32578-12-4)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.9b00880

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3-Methoxybenzoic acid (586-38-9) → 1-(3-methoxyphenyl)-2,2-dimethylpropan-1-one (32578-12-4) + Trimethylacetic acid (75-98-9)

Guidance literature:

With tert.-butyl lithium; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, pentane, -78 deg C, 45 min 2) up to r.t., 1h;

DOI:10.1021/jo00289a012

Reference yield:

tert.-butyl lithium (594-19-4) + m-anisoyl chloride (1711-05-3) → 1-(3-methoxyphenyl)-2,2-dimethylpropan-1-one (32578-12-4)

Guidance literature:

tert.-butyl lithium; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -78 ℃; for 0.5h;

m-anisoyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2019.151394

upstream raw materials:

3-methoxyphenyl bromide

pivaloyl chloride

carbon dioxide

3-Methoxybenzoic acid

Downstream raw materials:

α-tert-butyl-3-methoxybenzyl alcohol

Toluene-4-sulfonic acid 1-(3-methoxy-phenyl)-2,2-dimethyl-propyl ester

1-(2-hydroxy-5-methoxyphenyl)-2,2-dimethylpropan-1-one