2-ethoxy-1-fluoro-4-nitrobenzene

Base Information

• Chemical Name: 2-ethoxy-1-fluoro-4-nitrobenzene
• CAS No.: 1093656-34-8
• Molecular Formula: C8H8FNO3
• Molecular Weight: 185.155
• Hs Code.: 2909309090
• Mol file: 1093656-34-8.mol

Synonyms:2-ethoxy-1-fluoro-4-nitrobenzene;2-Ethoxy-1-fluoro-4-nitrobenzene2-Ethoxy-1-fluoro-4-nitrobenzene

Chemical Property of 2-ethoxy-1-fluoro-4-nitrobenzene

Chemical Property:

• PSA: 55.05000
• LogP: 2.65580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Ethoxy-1-fluoro-4-nitrobenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethoxy-1-fluoro-4-nitrobenzene

There total 1 articles about 2-ethoxy-1-fluoro-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.59%

ethyl iodide (75-03-6) + 2-fluoro-5-nitrophenol (22510-08-3) → 2-ethoxy-1-fluoro-4-nitrobenzene (1093656-34-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield: 95.0%

1-aza-18-crown-6 (33941-15-0) + 2-ethoxy-1-fluoro-4-nitrobenzene (1093656-34-8) → N-(4-nitro-2-ethoxyphenyl)aza[18]crown-6 ether

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 12h; Reflux;

DOI:10.1002/asia.201500956

Reference yield: 81.1%

2-ethoxy-1-fluoro-4-nitrobenzene (1093656-34-8) → 2-ethoxy-1-fluoro-4-aminobenzene (1262881-14-0)

Guidance literature:

With iron; ammonium chloride; In ethanol; at 80 ℃; for 2h;

upstream raw materials:

ethyl iodide

2-fluoro-5-nitrophenol

Downstream raw materials:

1-(2-Ethoxy-4-nitrophenyl)piperidin-2-one

2-ethoxy-1-fluoro-4-aminobenzene