ETHYL 4-METHOXYCARBONYLBENZOYLACETATE

Base Information

• Chemical Name: ETHYL 4-METHOXYCARBONYLBENZOYLACETATE
• CAS No.: 155877-84-2
• Molecular Formula: C13H14O5
• Molecular Weight: 250.251
• Mol file: 155877-84-2.mol

Synonyms:ETHYL 4-METHOXYCARBONYLBENZOYLACETATE;4-(METHOXYCARBONYL)-BETA-OXO-BENZENEPROPANOIC ACID ETHYL ESTER

Chemical Property of ETHYL 4-METHOXYCARBONYLBENZOYLACETATE

Chemical Property:

• PSA: 69.67000
• LogP: 1.60910

Purity/Quality:

4-(Methoxycarbonyl)-b-oxo-benzenepropanoicacidethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-METHOXYCARBONYLBENZOYLACETATE

There total 7 articles about ETHYL 4-METHOXYCARBONYLBENZOYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(2-ethoxycarbonyl-1-hydroxy-ethyl)-benzoic acid methyl ester → ethyl <4-(methoxycarbonyl)benzoyl>acetate (155877-84-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

DOI:10.1002/asia.201100154

Reference yield: 62.0%

Monomethyl terephthalate (1679-64-7) + magnesium bis(3-ethoxy-3-oxopropanoate) (37517-78-5) → ethyl <4-(methoxycarbonyl)benzoyl>acetate (155877-84-2)

Guidance literature:

Monomethyl terephthalate; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 3h;

magnesium bis(3-ethoxy-3-oxopropanoate); In tetrahydrofuran; acetonitrile; at 0 - 85 ℃;

Reference yield:

ethyl potassium malonate (6148-64-7) + 4-(Imidazole-1-carbonyl)-benzoic acid methyl ester (112497-47-9) → ethyl <4-(methoxycarbonyl)benzoyl>acetate (155877-84-2)

Guidance literature:

ethyl potassium malonate; With triethylamine; magnesium chloride; In tetrahydrofuran; at 25 ℃; for 6h;

4-(Imidazole-1-carbonyl)-benzoic acid methyl ester; In tetrahydrofuran; Reflux;

DOI:10.1021/acs.jafc.9b06360

upstream raw materials:

4-Methoxycarbonylbenzoyl chloride

methyl 4-formylbenzoate

Monomethyl terephthalate

magnesium bis(3-ethoxy-3-oxopropanoate)

Downstream raw materials:

methyl 4-(5-oxo-4,5-dihydroisoxazol-3-yl)benzoate

methyl (Z)-4-(5-oxo-4-{4-[4-(trifluoromethoxy)benzyloxy]benzylidene}-4,5-dihydroisoxazol-3-yl)benzoate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK". Page/Page column 58. . Retrieved 2012/11/08.
• 2、 Eyrolles, Laurence,Kagechika, Hiroyuki,Kawachi, Emiko,Fukasawa, Hiroshi,Iijima, Tohru,et al.. "Retinobenzoic Acids. 6. Retinoid Antagonists with a Heterocyclic Ring". . p. 1508 - 1517. Retrieved 2007/10/02.