PDE1-IN-1 (phosphate)

Base Information

Chemical Name:PDE1-IN-1 (phosphate)
CAS No.:1642303-38-5
Molecular Formula:C₂₉H₂₆FN₇O*H₃O₄P
Molecular Weight:605.565
Hs Code.:
Mol file:1642303-38-5.mol

Synonyms:

Suppliers and Price of PDE1-IN-1 (phosphate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
ITI214 98+%
10mg
$ 347.00

Crysdot
ITI214 98+%
5mg
$ 243.00

Crysdot
ITI214 98+%
100mg
$ 1459.00

Crysdot
ITI214 98+%
50mg
$ 1042.00

ChemScene
ITI-214 99.57%
50mg
$ 950.00

ChemScene
ITI-214 99.57%
5mg
$ 190.00

ChemScene
ITI-214 99.57%
10mg
$ 350.00

Cayman Chemical
ITI214
10mg
$ 520.00

Cayman Chemical
ITI214
5mg
$ 293.00

Cayman Chemical
ITI214
1mg
$ 65.00

Total 7 raw suppliers

Chemical Property of PDE1-IN-1 (phosphate)

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

ITI214 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description ITI214 is an inhibitor of phosphodiesterase 1 (PDE1; Ki = 0.058 nM). It is selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 μM). ITI214 (3 and 6 mg/kg) enhances novel object recognition in rats. It increases prefrontal cortex cAMP and cGMP levels in mice when administered at a dose of 50 mg/kg. ITI214 (0.1, 3, and 10 mg/kg) reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice.

Technology Process of PDE1-IN-1 (phosphate)

There total 12 articles about PDE1-IN-1 (phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1160521-50-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

: 1642303-38-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one mono-phosphate

Guidance literature:: With phosphoric acid; In acetonitrile; at 45 ℃; for 4h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

: 1520918-63-1
2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

: 1642303-38-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one mono-phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 10 h / 20 °C

1.2: 1 h / 10 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 1 h / 20 °C

2.2: 5 h / 20 °C

3.1: dmap; p-toluenesulfonyl chloride; triethylamine / tetrahydrofuran / 10 h / 50 °C

3.2: 2 h / 20 °C

4.1: N-chloro-succinimide; lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / Inert atmosphere

6.1: phosphoric acid / acetonitrile / 20 - 45 °C / Inert atmosphere

With dmap; N-chloro-succinimide; trifluorormethanesulfonic acid; phosphoric acid; palladium diacetate; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; p-toluenesulfonyl chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; toluene; acetonitrile;

Reference yield:

: 1228658-88-5
(6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

: 1642303-38-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one mono-phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide; lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

2: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / Inert atmosphere

3: phosphoric acid / acetonitrile / 20 - 45 °C / Inert atmosphere

With N-chloro-succinimide; phosphoric acid; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; toluene; acetonitrile;