1H-Benzimidazole-2-methanol,1,5-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-2-methanol,1,5-dimethyl-(9CI)
• CAS No.: 68426-72-2
• Molecular Formula: C10H12N2O
• Molecular Weight: 176.218
• Hs Code.: 2933990090
• Mol file: 68426-72-2.mol

Synonyms:1H-Benzimidazole-2-methanol,1,5-dimethyl-(9CI);(1,5-dimethyl-1H-benzimidazol-2-yl)methanol(SALTDATA: FREE);(1,5-dimethyl-1H-benzimidazol-2-yl)methanol;(1,5-dimethyl-2-benzimidazolyl)methanol;(1,5-dimethylbenzimidazol-2-yl)methanol

Chemical Property of 1H-Benzimidazole-2-methanol,1,5-dimethyl-(9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 365.081°C at 760 mmHg
• Flash Point: 174.595°C
• PSA: 38.05000
• Density: 1.194g/cm³
• LogP: 1.37400

Purity/Quality:

98% ^*data from raw suppliers

(1,5-Dimethyl-1H-benzimidazol-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-2-methanol,1,5-dimethyl-(9CI)

There total 5 articles about 1H-Benzimidazole-2-methanol,1,5-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(5-methyl-1H-benzimidazole-2-yl)methanol (20034-02-0) + methyl iodide (74-88-4) → (N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol (68426-72-2)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.5012/bkcs.2013.34.4.1272

Reference yield:

4-methyl-1,2-diaminobenzene (496-72-0) → 2-(hydroxymethyl)-1,6-dimethylbenzimidazole (155221-51-5) + (N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol (68426-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / Reflux

2: potassium carbonate / N,N-dimethyl-formamide

With hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.07.019

Reference yield:

(5-methyl-1H-benzimidazole-2-yl)methanol (20034-02-0) + methyl iodide (74-88-4) → 2-(hydroxymethyl)-1,6-dimethylbenzimidazole (155221-51-5) + (N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol (68426-72-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.07.019

upstream raw materials:

(5-methyl-1H-benzimidazole-2-yl)methanol

methyl iodide

4-methyl-1,2-diaminobenzene

Downstream raw materials:

C₂₁H₂₀N₂O₃

C₂₁H₂₀N₂O₃

1,5-dimethyl-1H-benzoimidazole-2-carbaldehyde

2-chloromethyl-1,5-dimethyl-1H-benzoimidazole