20034-02-0

Basic information

• Product Name: (6-Methyl-1H-benzimidazol-2-yl)methanol
• Synonyms: CHEMBRDG-BB 4011014;(6-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL;(5-methyl-1H-benzo[d]imidazol-2-yl)methanol;1H-Benzimidazole-2-methanol,5-methyl-(9CI);(5-methyl-1H-benzimidazol-2-yl)methanol;(6-Methyl-1H-benzimidazol-2-yl)methanol;Albb-003795;(6-methyl-1H-benzimidazol-2-yl)methanol(SALTDATA: FREE)
• CAS NO: 20034-02-0
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Product Categories: BENZIMIDAZOLE
• Mol File: 20034-02-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 203 °C
• Boiling Point: 416.3 °C at 760 mmHg
• Flash Point: 205.6 °C
• Appearance: /
• Density: 1.295 g/cm³
• Vapor Pressure: 1.12E-07mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.83±0.10(Predicted)
• CAS DataBase Reference: (6-Methyl-1H-benzimidazol-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Methyl-1H-benzimidazol-2-yl)methanol(20034-02-0)
• EPA Substance Registry System: (6-Methyl-1H-benzimidazol-2-yl)methanol(20034-02-0)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 20034-02-0(Hazardous Substances Data)

Usage

General Description

(6-Methyl-1H-benzimidazol-2-yl)methanol is a chemical compound with the molecular formula C9H10N2O. It is a benzimidazole derivative that contains a hydroxymethyl group attached to the benzimidazole ring. (6-Methyl-1H-benzimidazol-2-yl)methanol has been studied for its potential pharmacological activities, including its anti-inflammatory and antioxidant properties. It may also have applications in the field of medicinal chemistry for the development of novel drugs. The structural features of (6-Methyl-1H-benzimidazol-2-yl)methanol make it a valuable building block for the synthesis of various bioactive compounds. Overall, (6-Methyl-1H-benzimidazol-2-yl)methanol is a versatile chemical that has potential for various pharmaceutical and research purposes.

InChI:InChI=1/C9H10N2O/c1-6-2-3-7-8(4-6)11-9(5-12)10-7/h2-4,12H,5H2,1H3,(H,10,11)

Upstream product

• 79-14-1 glycolic Acid 
• 496-72-0 4-methyl-1,2-diaminobenzene 

Downstream Products

• 883541-93-3 C₉H₈N₂O 
• 155221-51-5 2-(hydroxymethyl)-1,6-dimethylbenzimidazole 
• 68426-72-2 (N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol 
• 37735-10-7 1,5-dimethyl-1H-benzoimidazole-2-carbaldehyde 
• 1357162-35-6 C₂₁H₂₀N₂O₃ 
• 1357162-26-5 C₂₁H₂₀N₂O₃ 
• 99459-47-9 5-methyl-1H-benzo[d]imidazole-2-carboxylic acid 
• 80567-68-6 2-(chloromethyl)-5-methyl-1H-benzo[d]imidazole 

Relevant articles and documents

Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C2 Synthon

D-fructose, a biomass-derived carbohydrate has been identified as an environmentally benign C2 synthon in the preparation of synthetically useful 2-hydroxymethylbenzimidazole derivatives by coupling with 1,2-phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF3.OEt2 (20 mol%), TBHP (5.5 M, decane) (1.0 equiv.) in CH3CN at 90 °C for 1 h. The pivotal features of this method include metal-free conditions, short time, good functional group tolerance, gram scale feasibility and the synthesis of benzimidazole fused 1,4-oxazine. Control studies with conventional C2 synthons did not produce the desired product, thus suggesting a new reaction pathway from D-fructose.

Efficient Synthesis and Biological Activity of Novel Indole Derivatives as VEGFR-2 Tyrosine Kinase Inhibitors

A series of novel indole derivatives were synthesized as potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase. Among those, compound 10b demonstrated the highest growth inhibition rate of 66.7% against the VEGFR-2 tyrosine kinase at 10 μM which indicates that indole-benzothiazole might be the favorable structure. The binding mode of compound 10b with VEGFR-2 tyrosine kinase was evaluated by molecular docking.

Synthesis and antinociceptive activity of meperidine-like benzimidazole derivatives

(Graph presented) A series of novel benzimidazole derivatives have been prepared and characterized by IR, 1H-NMR spectroscopic data and elemental analysis. All the final compounds were screened for their antinociceptive activities with tail flick test. Among the synthesized compounds 3a, 4a, 4c, 8a, 9a exhibited significant antinociceptive activity. Compound 9a was found to have the highest antinociceptive activity at both 60 minutes and 120 minutes. Additionally, compounds 3a, 4a, 8a and 9a showed naloxone-reversible antinociceptive activity.