2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Base Information

• Chemical Name: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• CAS No.: 137428-09-2
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 137428-09-2.mol

Synonyms:2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;N-CBZ-2-PIPERIDINEACETIC ACID;N-CARBOBENZYLOXY-2-PIPERIDINE ACETIC ACID;2-(1-((Benzyloxy)carbonyl)piperidin-2-yl)acetic acid

Chemical Property of 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Chemical Property:

• Boiling Point: 460.1±28.0 °C(Predicted)
• PKA: 4.75±0.10(Predicted)
• Density: 1.216±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(1-((Benzyloxy)carbonyl)piperidin-2-yl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

There total 20 articles about 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzyl chloroformate (501-53-1,94274-21-2) + (R)-2-(piperidin-2'-yl)ethanoic acid (19832-04-3,55049-18-8,64625-19-0,69222-96-4) → (R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid (1036403-99-2,137428-09-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 18.33h;

DOI:10.1021/jo101776y

Reference yield: 76.0%

(R)-1-(benzyloxycarbonyl)-2-(2-oxoethyl)piperidine (143264-57-7) → (R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid (1036403-99-2,137428-09-2)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 1h;

DOI:10.1021/jo800749t

Reference yield:

2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester (39945-50-1) → 2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid (137428-09-2)

Guidance literature:

With sodium hypochlorite; sodium chlorite; disodium hydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; acetonitrile; at 35 ℃;

upstream raw materials:

2(RS)-(2-hydroxyethyl)piperidine

benzyl chloroformate

2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester

(3(2(2R)),4S,5R)-3-[2-((N-benzyloxycarbonyl)piperidin-2-yl)-1-oxoethyl]-4-methyl-5-phenyl-2-oxazolidinone

Downstream raw materials:

(S)-2-(piperidin-2-yl)ethanoic acid

(R)-2-(piperidin-2'-yl)ethanoic acid

(2S,2(2S))-2-amino-2-(piperidin-2-yl)ethanoic acid

(2S,2(2R))-2-amino-2-(piperidin-2-yl)ethanoic acid