(S)-2-(Piperidin-2-yl)acetic acid

Base Information

• Chemical Name: (S)-2-(Piperidin-2-yl)acetic acid
• CAS No.: 64625-19-0
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90357575
• Nikkaji Number: J1.574.280A
• Mol file: 64625-19-0.mol

Synonyms:(S)-2-(Piperidin-2-yl)acetic acid;64625-19-0;2-[(2S)-piperidin-2-yl]acetic acid;(S)-2-(Piperidin-2-yl)aceticacid;SCHEMBL288736;DTXSID90357575;AKOS006330047;CS-0271840;(S)-2-Piperidineacetic acid hydrochloride,97%;EN300-816455;A904876

Chemical Property of (S)-2-(Piperidin-2-yl)acetic acid

Chemical Property:

• PSA: 49.33000
• LogP: 0.93200
• Storage Temp.: 2-8°C
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(Piperidin-2-yl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CC(=O)O
• Isomeric SMILES: C1CCN[C@@H](C1)CC(=O)O

Technology Process of (S)-2-(Piperidin-2-yl)acetic acid

There total 33 articles about (S)-2-(Piperidin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid (1036403-99-2,137428-09-2) → (R)-2-(piperidin-2'-yl)ethanoic acid (19832-04-3,55049-18-8,64625-19-0,69222-96-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 760.051 Torr;

DOI:10.1021/jo800749t

Reference yield: 90.6%

N-Camphanoylhomopipecolinsaeure (111504-88-2) → (R)-2-(piperidin-2'-yl)ethanoic acid (19832-04-3,55049-18-8,64625-19-0,69222-96-4)

Guidance literature:

With sulfuric acid; at 95 ℃; for 4h;

Reference yield: 76.0%

(2R)-2-(2-methoxyethyl)piperidine (68419-38-5) → (R)-2-(piperidin-2'-yl)ethanoic acid (19832-04-3,55049-18-8,64625-19-0,69222-96-4)

Guidance literature:

(2R)-2-(2-methoxyethyl)piperidine; With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; In water; ethyl acetate; at 5 - 20 ℃; for 0.833333h; pH=8.0 - 9.0;

With hydrogenchloride; sodium chlorite; In water; ethyl acetate; at 20 - 33 ℃; for 16.5h; pH=5.0;

upstream raw materials:

(2S)-2-(2-methoxyethyl)piperidine

(S)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid

tert-butyl (S)-piperidine-2-acetate

(2S)-methoxycarbonylmethylpiperidin

Downstream raw materials:

(S)-2-(methoxycarbonylmethyl)piperidine-1-carboxylic acid tert-butyl ester

(S)-2-{1-[(tert-butoxy)carbonyl]piperidin-2-yl}acetic acid

(R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl) acetic acid

(R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid