3-Ethynyltetrahydrofuran

Base Information

• Chemical Name: 3-Ethynyltetrahydrofuran
• CAS No.: 1100987-19-6
• Molecular Formula: C6H8O
• Molecular Weight: 96.1289
• Mol file: 1100987-19-6.mol

Synonyms:3-Ethynyltetrahydrofuran;3-ethynyloxolane

Chemical Property of 3-Ethynyltetrahydrofuran

Chemical Property:

• Boiling Point: 110.1±29.0 °C(Predicted)
• PSA: 9.23000
• Density: 0.95±0.1 g/cm3(Predicted)
• LogP: 0.65610

Purity/Quality:

97% ^*data from raw suppliers

3-Ethynyltetrahydrofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethynyltetrahydrofuran

There total 4 articles about 3-Ethynyltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydrofuran-3-carboxaldehyde (79710-86-4) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → (±)-3-ethynyltetrahydrofuran (1100987-19-6)

Guidance literature:

With potassium carbonate; In methanol; diethyl ether; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.11.014

Reference yield:

tetrahydrofuran-3-carboxaldehyde (79710-86-4) + methanol (67-56-1) → (±)-3-ethynyltetrahydrofuran (1100987-19-6)

Guidance literature:

With dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate; at 20 ℃; for 2h;

Reference yield:

3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1) → (±)-3-ethynyltetrahydrofuran (1100987-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: potassium carbonate / diethyl ether; methanol / 3 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; Dess-Martin periodane; In methanol; diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2016.11.014

upstream raw materials:

tetrahydrofuran-3-carboxaldehyde

methanol

3-tetrahydrofuranmethanol

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate