benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate

Base Information

• Chemical Name: benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate
• CAS No.: 1227456-92-9
• Molecular Formula: C15H20N2O2
• Molecular Weight: 260.336
• Hs Code.: 2933990090
• Mol file: 1227456-92-9.mol

Synonyms:benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate;2-Cbz-2,7-diaza-spiro[3.5]nonane

Chemical Property of benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate

Chemical Property:

• PSA: 41.57000
• LogP: 2.27530
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

BENZYL 2,7-DIAZASPIRO[3.5]NONANE-2-CARBOXYLATE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate

There total 4 articles about benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

2-benzyl 7-(tert-butyl) 2,7-diazaspiro[3.5]nonane-2,7-dicarboxylate (1345728-66-6) → benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate (1227456-92-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.8b04532

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate (1227456-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jacs.8b04532

Reference yield:

tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9) → benzyl 2,7-diazaspiro[3.5]nonane-2-carboxylate (1227456-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jacs.8b04532

upstream raw materials:

2-benzyl 7-(tert-butyl) 2,7-diazaspiro[3.5]nonane-2,7-dicarboxylate

tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride

benzyl chloroformate

2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester

Downstream raw materials:

C₂₅H₂₅F₃N₆O₂

Refernces

• 1、 Chen, Yiding,Murray, Philip R. D.,Davies, Alyn T.,Willis, Michael C.. "Direct Copper-Catalyzed Three-Component Synthesis of Sulfonamides". supporting information. p. 8781 - 8787. Retrieved 2018/07/29.