1-(p-Toluenesulfonyl)hoMopiperazine, 95%

Base Information

• Chemical Name: 1-(p-Toluenesulfonyl)hoMopiperazine, 95%
• CAS No.: 872103-28-1
• Molecular Formula: C12H18N2O2S
• Molecular Weight: 254.353
• Mol file: 872103-28-1.mol

Synonyms:1-(p-Toluenesulfonyl)hoMopiperazine, 95%

Chemical Property of 1-(p-Toluenesulfonyl)hoMopiperazine, 95%

Chemical Property:

• PSA: 57.79000
• LogP: 2.32650

Purity/Quality:

97% ^*data from raw suppliers

1-Tosyl-1,4-diazepanehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hexahydro-1-[(4-methylphenyl)sulfonyl]-1H-1,4-diazepine (Fasudil Impurity 16) is an impurity of Fasudil (F150018), a selective ROCK inhibitor.

Technology Process of 1-(p-Toluenesulfonyl)hoMopiperazine, 95%

There total 1 articles about 1-(p-Toluenesulfonyl)hoMopiperazine, 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4-Diazacycloheptane (505-66-8) + p-toluenesulfonyl chloride (98-59-9) → C12H18N2O2S (872103-28-1)

Guidance literature:

With acetic acid; at 60 ℃; for 0.0666667h; Sonication; Irradiation;

DOI:10.1039/c1lc20765b

Reference yield: 88.0%

C12H18N2O2S (872103-28-1) + allyl bromide (106-95-6) → 1-allyl-4-tosyl-1,4-diazepane

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol503748t

Reference yield: 77.0%

C12H18N2O2S (872103-28-1) + dibenzoyl peroxide (94-36-0) → C19H22N2O4S

Guidance literature:

With dipotassium hydrogenphosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00828

upstream raw materials:

1,4-Diazacycloheptane

p-toluenesulfonyl chloride