Chemical Property of Homopiperazine
Chemical Property:
- Appearance/Colour:white to light yellow crystalline mass
- Vapor Pressure:1.57mmHg at 25°C
- Melting Point:38-40 ºC
- Refractive Index:1.4378 (estimate)
- Boiling Point:169 ºC at 760 mmHg
- PKA:11.02±0.20(Predicted)
- Flash Point:64.4 ºC
- PSA：24.06000
- Density:0.861 g/cm3
- LogP:0.22690
- Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
- Sensitive.:Air Sensitive & Hygroscopic
- Water Solubility.:Soluble in water.
- XLogP3:-0.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:100.100048391
- Heavy Atom Count:7
- Complexity:39.3
- Purity/Quality:
-
99% *data from raw suppliers
Homopiperazine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi; 
C
- Hazard Codes:C,Xi
- Statements:
21-34
- Safety Statements:
26-36/37/39-45-27
- MSDS Files:
-
Useful:
- Canonical SMILES:C1CNCCNC1
-
Uses
It can be used as organic and pharmaceutical synthesis intermediates, for example, being applied to the synthesis of fasudil hydrochloride.
Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer disease. pharmaceutical intermediate Homopiperazine is used to prepare 1,4-bis-(2-thiazolyl)-1,4-diazacycloheptane by reacting with 2-bromo-thiazole. It acts as an intermediate for repaglinide and fasudil hydrochloride. It is also used in the preparation of potent H3 receptor antagonists, which is used for the treatment of neurodegenerative conditions. Further, it is used in vesicant, cosmetic, emulsifier and energetic material. It acts as a corrosion inhibitor for iron. In pharmaceuticals, it is employed as antipyretic and reducing blood sugar, adiposity, calm, antipsychotic and anti-nervous.
