7-Benzyl-7-azabicyclo[2.2.1]heptane-1-methanamine

Base Information

• Chemical Name: 7-Benzyl-7-azabicyclo[2.2.1]heptane-1-methanamine
• CAS No.: 1193090-83-3
• Molecular Formula: C14H20N2
• Molecular Weight: 216.326
• Hs Code.: 2933990090
• Mol file: 1193090-83-3.mol

Synonyms:7-Benzyl-7-azabicyclo[2.2.1]heptane-1-methanamine;7-(phenylmethyl)-7-Azabicyclo[2.2.1]heptane-1-methanamine

Chemical Property of 7-Benzyl-7-azabicyclo[2.2.1]heptane-1-methanamine

Chemical Property:

• PSA: 29.26000
• LogP: 2.78050

Purity/Quality:

98%min ^*data from raw suppliers

(7-Benzyl-7-azabicyclo[2.2.1]heptan-1-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Benzyl-7-azabicyclo[2.2.1]heptane-1-methanamine

There total 1 articles about 7-Benzyl-7-azabicyclo[2.2.1]heptane-1-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-benzyl-7-azabicyclo[2.2.1]heptane-1-carbonitrile (1087789-01-2) → C-(7-benzyl-7-azabicyclo[2.2.1]hept-1-yl)-methylamine (1193090-83-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield: 95.0%

2-bromo-pyridine (109-04-6) + C-(7-benzyl-7-azabicyclo[2.2.1]hept-1-yl)-methylamine (1193090-83-3) → (7-benzyl-7-azabicyclo[2.2.1]hept-1-ylmethyl)-pyridin-2-yl-amine (1193090-84-4)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 70 ℃; for 50h; Inert atmosphere;

Reference yield: 47.0%

3-Bromopyridine (626-55-1,163928-56-1) + C-(7-benzyl-7-azabicyclo[2.2.1]hept-1-yl)-methylamine (1193090-83-3) → (7-benzyl-7-azabicyclo[2.2.1]hept-1-ylmethyl)-pyridin-3-yl-amine (1193090-85-5)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; di-t-butyl-{1-[2-(dicyclohexylphosphanyl)ferrocenyl]ethyl}phosphine; sodium t-butanolate; In toluene; at 70 ℃; for 50h; Inert atmosphere;

DOI:10.1002/ejoc.200901277

upstream raw materials:

7-benzyl-7-azabicyclo[2.2.1]heptane-1-carbonitrile

Downstream raw materials:

(7-benzyl-7-azabicyclo[2.2.1]hept-1-ylmethyl)-pyridin-2-yl-amine

(7-benzyl-7-azabicyclo[2.2.1]hept-1-ylmethyl)-pyridin-3-yl-amine