6-(2,6-difluorophenyl)-5-fluoropicolinic acid

Base Information

Chemical Name:6-(2,6-difluorophenyl)-5-fluoropicolinic acid
CAS No.:1210419-19-4
Molecular Formula:C12H6F3NO2
Molecular Weight:253.18
Hs Code.:
Mol file:1210419-19-4.mol

Synonyms:6-(2,6-difluorophenyl)-5-fluoropicolinic acid;2-Pyridinecarboxylic acid, 6-(2,6-difluorophenyl)-5-fluoro-

Suppliers and Price of 6-(2,6-difluorophenyl)-5-fluoropicolinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(2,6-Difluorophenyl)-5-fluoropicolinicAcid
50mg
$ 220.00

Crysdot
6-(2,6-Difluorophenyl)-5-fluoropicolinicacid 95+%
250mg
$ 445.00

ChemScene
2-Pyridinecarboxylicacid,6-(2,6-difluorophenyl)-5-fluoro- 99.89%
250mg
$ 280.00

ChemScene
2-Pyridinecarboxylicacid,6-(2,6-difluorophenyl)-5-fluoro- 99.89%
100mg
$ 168.00

ChemScene
2-Pyridinecarboxylicacid,6-(2,6-difluorophenyl)-5-fluoro- 99.89%
5g
$ 3200.00

ChemScene
2-Pyridinecarboxylicacid,6-(2,6-difluorophenyl)-5-fluoro- 99.89%
1g
$ 1020.00

Chemenu
6-(2,6-Difluorophenyl)-5-fluoropicolinicacid 95%
1g
$ 574.00

Alichem
6-(2,6-Difluorophenyl)-5-fluoropicolinicacid
1g
$ 524.70

Total 8 raw suppliers

Chemical Property of 6-(2,6-difluorophenyl)-5-fluoropicolinic acid

Chemical Property:

PSA：50.19000
LogP:2.86410

Purity/Quality:

97% ^*data from raw suppliers

6-(2,6-Difluorophenyl)-5-fluoropicolinicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-(2,6-difluorophenyl)-5-fluoropicolinic acid

There total 7 articles about 6-(2,6-difluorophenyl)-5-fluoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1620011-33-7
methyl 6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylate

: 1210419-19-4
6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylic acid

Guidance literature:: methyl 6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylate; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; pH=2;

Reference yield: 49.0%

: 1210419-18-3
2-(2',6'-difluorophenyl)-3-fluoro-6-methylpyridine

: 1210419-19-4
6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylic acid

Guidance literature:: With potassium permanganate; In water; Reflux;
DOI:10.1021/ml400307j

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1210419-19-4
6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium fluoride / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; tetrahydrofuran / 1 h / 60 °C

2.1: potassium permanganate / water / Reflux

2.2: pH 1

With potassium fluoride; potassium permanganate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; water; 1.1: Suzuki Coupling;