methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

Base Information

Chemical Name:methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate
CAS No.:1355011-17-4
Molecular Formula:C₁₃H₉F₃N₂O₂
Molecular Weight:282.222
Hs Code.:

Synonyms:methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

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Chemical Property of methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

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Technology Process of methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

There total 5 articles about methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1355011-17-4
methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium fluoride / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; tetrahydrofuran / 1 h / 60 °C

2.1: potassium permanganate / water / Reflux

2.2: pH 1

3.1: nitric acid; sulfuric acid / 2 h / 20 °C

4.1: sulfuric acid / 18 h / 20 °C

5.1: acetic acid; iron / 16 h / 20 °C

With potassium fluoride; potassium permanganate; sulfuric acid; nitric acid; iron; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; water; 1.1: Suzuki Coupling;

Reference yield:

: 162101-25-9
2,6-difluorophenylboronic acid

: 1355011-17-4
methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium fluoride / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; tetrahydrofuran / 1 h / 60 °C

2.1: potassium permanganate / water / Reflux

2.2: pH 1

3.1: nitric acid; sulfuric acid / 2 h / 20 °C

4.1: sulfuric acid / 18 h / 20 °C

5.1: acetic acid; iron / 16 h / 20 °C

With potassium fluoride; potassium permanganate; sulfuric acid; nitric acid; iron; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; water; 1.1: Suzuki Coupling;

Reference yield:

: 1210419-18-3
2-(2',6'-difluorophenyl)-3-fluoro-6-methylpyridine

: 1355011-17-4
methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium permanganate / water / Reflux

1.2: pH 1

2.1: nitric acid; sulfuric acid / 2 h / 20 °C

3.1: sulfuric acid / 18 h / 20 °C

4.1: acetic acid; iron / 16 h / 20 °C

With potassium permanganate; sulfuric acid; nitric acid; iron; acetic acid; In water;