Hesperetin 3,4-Diacetate

Base Information

• Chemical Name: Hesperetin 3,4-Diacetate
• CAS No.: 147711-15-7
• Molecular Formula: C₂₀H₁₈O₈
• Molecular Weight: 386.358
• Mol file: 147711-15-7.mol

Synonyms:Hesperetin 3,4-Diacetate;5-(Acetyloxy)-2-[3-(acetyloxy)-4-Methoxyphenyl]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one;Hesperetin 3,4-di-O-Acetyl;Hesperetin 3',5-Diacetate

Chemical Property of Hesperetin 3,4-Diacetate

Chemical Property:

• PSA: 108.36000
• LogP: 2.95790
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Very Slightly)

Purity/Quality:

rac-Hesperetin3’,5-Diacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hesperidin (H281185) derivative.

Technology Process of Hesperetin 3,4-Diacetate

There total 4 articles about Hesperetin 3,4-Diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one (6274-73-3,73489-97-1) → 2-(3-acetoxy-4-methoxyphenyl)-7-hydroxy-4-oxochroman-5-yl acetate (147711-15-7)

Guidance literature:

With 1H-imidazole; thiophenol; In 1-methyl-pyrrolidin-2-one; at 0 ℃; Inert atmosphere;

DOI:10.1055/s-0031-1290756

Reference yield: 55.0%

3',5,7-triacetoxy-4'-methoxyflavanone (6274-73-3) → 5,7-diacetoxy-3'-hydroxy-4'-methoxyflavanone + 5,3'-diacetoxy-7-hydroxy-4'-methoxyflavanone (147711-15-7)

Guidance literature:

In tetrahydrofuran; butan-1-ol; at 42 - 45 ℃; porcine pancreas type II lipase;

DOI:10.1039/c39930000027

Reference yield:

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone (520-33-2,41001-90-5,69097-99-0) → 5,3'-diacetoxy-7-hydroxy-4'-methoxyflavanone (147711-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 55 percent / tetrahydrofuran; butan-1-ol / 42 - 45 °C / porcine pancreas type II lipase

With pyridine; In tetrahydrofuran; butan-1-ol;

DOI:10.1039/c39930000027

upstream raw materials:

3',5,7-triacetoxy-4'-methoxyflavanone

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

(S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one

hesperetin

Downstream raw materials:

4'-O-methyl-8-isoprenyl eriodictyol