3',5,7-Triacetoxy-4'-hydroxyflavanone

Base Information

• Chemical Name: 3',5,7-Triacetoxy-4'-hydroxyflavanone
• CAS No.: 6274-73-3
• Molecular Formula: C22H20O9
• Molecular Weight: 428.395
• NSC Number: 37458
• ChEMBL ID: CHEMBL520468
• Mol file: 6274-73-3.mol

Synonyms:NSC37458;NSC-37458;Hesperetic triacetate;CHEMBL520468;FT-0669142

Chemical Property of 3',5,7-Triacetoxy-4'-hydroxyflavanone

Chemical Property:

• Vapor Pressure: 6.91E-14mmHg at 25°C
• Boiling Point: 589.8°Cat760mmHg
• Flash Point: 256.3°C
• Density: 1.318g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 8
• Exact Mass: 428.11073221
• Heavy Atom Count: 31
• Complexity: 705

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1=CC2=C(C(=O)CC(O2)C3=CC(=C(C=C3)OC)OC(=O)C)C(=C1)OC(=O)C

Technology Process of 3',5,7-Triacetoxy-4'-hydroxyflavanone

There total 8 articles about 3',5,7-Triacetoxy-4'-hydroxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone (520-33-2,41001-90-5,69097-99-0) + acetic anhydride (108-24-7) → 3',5,7-triacetoxy-4'-methoxyflavanone (6274-73-3)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 23h;

DOI:10.1021/jm00136a011

Reference yield: 84.0%

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone (520-33-2,41001-90-5,69097-99-0) + acetyl chloride (75-36-5) → 3',5,7-triacetoxy-4'-methoxyflavanone (6274-73-3)

Guidance literature:

With pyridine; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bioorg.2015.09.005

Reference yield:

acetic anhydride (108-24-7) + hesperetin (520-33-2,41001-90-5,69097-99-0) → (S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one (6274-73-3,73489-97-1)

Guidance literature:

With pyridine; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0031-1290756

upstream raw materials:

acetyl chloride

hesperetin

hesperidin

acetic anhydride

Downstream raw materials:

3',5-dihydroxy-4'-methoxy-7-(sulfopropoxy)flavone potassium salt

diosmetin

5-Hydroxy-4'-methoxy-7,3'-diacetoxy-flavanon

5,3'-diacetoxy-7-hydroxy-4'-methoxyflavanone