6274-73-3

Basic information

• Product Name: (2R)-2-[3-(acetyloxy)-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl diacetate
• CAS NO: 6274-73-3
• Molecular Formula: C₂₂H₂₀O₉
• Molecular Weight: 428.3888
• Mol File: 6274-73-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 589.8°C at 760 mmHg
• Flash Point: 256.3°C
• Density: 1.318g/cm³
• Vapor Pressure: 6.91E-14mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: (2R)-2-[3-(acetyloxy)-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-[3-(acetyloxy)-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl diacetate(6274-73-3)
• EPA Substance Registry System: (2R)-2-[3-(acetyloxy)-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl diacetate(6274-73-3)

Safety Data

• Hazardous Substances Data: 6274-73-3(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R)-2-[3-(acetyloxy)-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl diacetate" is a complex organic molecule. It is composed of a 2H-chromene ring structure with two acetyl groups attached to the 3 and 4 positions, a methoxy group attached to the 4 position, and a carbonyl group at the 4 position. The molecule is a diacetate, meaning it contains two acetate groups. (2R)-2-[3-(acetyloxy)-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl diacetate has potential applications in pharmaceuticals, medicinal chemistry, and organic synthesis due to its unique structure and functional groups. Further research and studies may be needed to explore its specific properties and potential uses.

Upstream product

• 75-36-5 acetyl chloride 
• 520-33-2 hesperetin 
• 520-26-3 hesperidin 
• 108-24-7 acetic anhydride 
• 520-33-2 (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone 

Downstream Products

• 102548-67-4 5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-3-bromo-chroman-4-one 
• 3162-05-8 3',5,7-triacetoxy-4'-methoxyflavone 
• 128373-97-7 Acetic acid 4-[3-(3-acetoxy-4-methoxy-phenyl)-propyl]-3,5-dihydroxy-phenyl ester 
• 128373-98-8 Acetic acid 5-acetoxy-2-[3-(3-acetoxy-4-methoxy-phenyl)-propyl]-3-hydroxy-phenyl ester 
• 147711-15-7 5,3'-diacetoxy-7-hydroxy-4'-methoxyflavanone 
• 3316-45-8 5-Hydroxy-4'-methoxy-7,3'-diacetoxy-flavanon 
• 1268140-15-3 4'-O-methyl-8-isoprenyl eriodictyol 
• 147711-15-7 2-(3-acetoxy-4-methoxyphenyl)-7-hydroxy-4-oxochroman-5-yl acetate 
• 70412-86-1 3',5-dihydroxy-4'-methoxy-7-(sulfopropoxy)flavone potassium salt 
• 520-34-3 diosmetin 

Relevant articles and documents

Synthesis, characterization, anti-inflammatory and anti-proliferative activity against MCF-7 cells of O-alkyl and O-acyl flavonoid derivatives

A series of O-alkyl and O-acyl flavonoid derivatives was synthesized in high efficiency. Alkylation and acylation of 5-hydroxyflavonoids showed that the low reactivity hydroxyl group, 5-OH, well reacted with strong reagents whereas with weaker reagents, the different products were obtained dependently on structural characteristic of ring C of respective flavonoid. In order to evaluate anti-inflammatory activity, all compounds were tested for in vitro inhibition of bovine serum albumin denaturation and in vivo inhibition of carrageenan-induced mouse paw edema. Among them, the compounds 3, 3b, 4b and 4c demonstrated more effective anti-inflammatory activity than standard drugs (diclofenac sodium and ketoprofen) in both tests. Meanwhile, the flavonoids 2, 2c, 3a and 4b displayed anti-proliferative activity against MCF-7 cell lines. Triacetyl derivative of hesperetin 4b inducing degradation of DNA in MCF-7 cells was observed.

Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships

A series of 28 flavonoid derivatives containing a N-benzylpiperazine chain have been synthesized and tested for their ability to modulate multidrug resistance (MDR) in vitro. At 5 μM, most compounds potentiated doxorubicin cytotoxicity on resistant K562/DOX cells. They were also able to increase the intracellular accumulation of JC-1, a fluorescent molecule recently described as a probe of P-glycoprotein-mediated MDR. This suggests that these compounds act, at least in part, by inhibiting P-glycoprotein activity. As in other studies, lipophilicity was shown to influence MDR- modulating activity but was not the only determinant. Diverse di- and trimethoxy substitutions on N-benzyl were examined and found to affect the activity differently. The most active compounds had a 2,3,4- trimethoxybenzylpiperazine chain attached to either a flavone or a flavanone moiety (13, 19, 33, and 37) and were found to be more potent than verapamil.

Dihydrochalcone sweeteners. A study of the atypical temporal phenomena

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