(3ALPHA)-OLEAN-12-ENE-3,28-DIOL

Base Information

• Chemical Name: (3ALPHA)-OLEAN-12-ENE-3,28-DIOL
• CAS No.: 55869-95-9
• Molecular Formula: C₃₀H₅₀O₂
• Molecular Weight: 442.726
• Mol file: 55869-95-9.mol

Synonyms:(3ALPHA)-OLEAN-12-ENE-3,28-DIOL

Chemical Property of (3ALPHA)-OLEAN-12-ENE-3,28-DIOL

Chemical Property:

• Melting Point: 242-243 °C
• Boiling Point: 520.5±50.0 °C(Predicted)
• PKA: 15.09±0.10(Predicted)
• PSA: 40.46000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 7.14130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3ALPHA)-OLEAN-12-ENE-3,28-DIOL

There total 52 articles about (3ALPHA)-OLEAN-12-ENE-3,28-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Oleanolic acid (508-02-1) → erythrodiol (545-48-2,55869-95-9,118204-21-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.3390/molecules23071552

Reference yield: 95.0%

(3β)-3-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-olean-12-en-28-ol (152487-61-1) → erythrodiol (545-48-2,55869-95-9,118204-21-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 55 ℃; for 12h;

DOI:10.1021/ja00072a064

Reference yield: 85.0%

ursolic acid (77-52-1) → erythrodiol (545-48-2,55869-95-9,118204-21-0)

Guidance literature:

ursolic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;

With water; In tetrahydrofuran;

DOI:10.1134/S1068162011030101

upstream raw materials:

myricadiol

Oleanolic acid

oleanolic acid methyl ester

sodium ethanolate

Downstream raw materials:

3-oxoolean-12-en-28-al

erythrodiol diacetate

3β-acetoxy-28-hydroxy-ole-12-ene

28-O-acetylerythrodiol

Refernces

• 1、 Serbian, Immo,Csuk, René. "An improved scalable synthesis of α- and β-amyrin". . . Retrieved 2018/07/13.
• 2、 Bian, Linglin,Cao, Shining,Cheng, Lihong,Nakazaki, Atsuo,Nishikawa, Toshio,Qi, Jianhua. "Semi-synthesis and Structure–Activity Relationship of Neuritogenic Oleanene Derivatives". supporting information. p. 1972 - 1977. Retrieved 2018/09/06.