2,4-Difluorophenyl acetic acid

Base Information

• Chemical Name: 2,4-Difluorophenyl acetic acid
• CAS No.: 141060-00-6
• Molecular Formula: C8H5ClF2O
• Molecular Weight: 190.577
• Hs Code.: 2916399090
• Mol file: 141060-00-6.mol

Synonyms:2,4-Difluorophenylacetylchloride99%

Chemical Property of 2,4-Difluorophenyl acetic acid

Chemical Property:

• PSA: 17.07000
• LogP: 2.27270

Purity/Quality:

95% ^*data from raw suppliers

2,4-Difluorophenylacetylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Difluorophenyl acetic acid

There total 2 articles about 2,4-Difluorophenyl acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

2,4-difluorophenylacetic acid (81228-09-3) → 2-(2,4-difluorophenyl)acetyl chloride (141060-00-6)

Guidance literature:

With phosgene; 4-(N,N-dipropylamino)pyridine; In toluene; Reagent/catalyst; Reflux;

Reference yield:

oxalyl dichloride (79-37-8) + 2,4-difluorophenylacetic acid (81228-09-3) → 2-(2,4-difluorophenyl)acetyl chloride (141060-00-6)

Guidance literature:

In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-(2,4-difluorophenyl)acetyl chloride (141060-00-6) → 1-diazo-3-(2,4-difluorophenyl)propan-2-one (1326236-24-1)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1002/asia.201100089

upstream raw materials:

2,4-difluorophenylacetic acid

oxalyl dichloride

Downstream raw materials:

2-(2,4-difluorophenyl)-1-(4-methylsulfanylphenyl)ethanone

[2-(2,4-Difluoro-phenyl)-acetyl]-thiourea

C₁₉H₂₀F₂N₂O₃

3-tert-butoxycarbonylamino-4-(2,4-difluoro-phenyl)-butyric acid

Refernces

• 1、 Chou, Chun-Ming,Tung, Yu-Wen,Isobe, Minoru. "Molecular mechanism of Symplectoteuthis bioluminescence - Part 4: Chromophore exchange and oxidation of the cysteine residue". . p. 4177 - 4188. Retrieved 2014.
• 2、 Dziuk, B?a?ej,Kafarski, Pawe?,Pirat, Jean-Luc,Talma, Micha?,Wanat, Weronika. "Phosphonic acid analogs of fluorophenylalanines as inhibitors of human and porcine aminopeptidases N: Validation of the importance of the substitution of the aromatic ring". . . Retrieved 2020/05/04.
• 3、 -. "Preparation method of acyl chloride". Paragraph 0060; 0061. . Retrieved 2016/11/28.