4-Fluoro-2-(methylsulfonyl)nitrobenzene

Base Information

• Chemical Name: 4-Fluoro-2-(methylsulfonyl)nitrobenzene
• CAS No.: 78228-02-1
• Molecular Formula: C₇H₆FNO₄S
• Molecular Weight: 219.193
• Hs Code.: 2904909090
• Mol file: 78228-02-1.mol

Synonyms:4-Fluoro-2-(methylsulfonyl)nitrobenzene;4-fluoro-2-(methylsulfonyl)-1-nitrobenzene

Chemical Property of 4-Fluoro-2-(methylsulfonyl)nitrobenzene

Chemical Property:

• Melting Point: 94-97.5 °C
• Boiling Point: 410.0±45.0 °C(Predicted)
• PSA: 88.34000
• Density: 1.488±0.06 g/cm3(Predicted)
• LogP: 2.74140
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Fluoro-2-(methylsulfonyl)nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-2-(methylsulfonyl)nitrobenzene

There total 2 articles about 4-Fluoro-2-(methylsulfonyl)nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(5-fluoro-2-nitrophenyl)(methyl)sulfane → 4-fluoro-2-(methylsulfonyl)-1-nitrobenzen (78228-02-1)

Guidance literature:

With dihydrogen peroxide; In acetic acid;

DOI:10.1016/S0022-1139(00)81286-5

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) → 4-fluoro-2-(methylsulfonyl)-1-nitrobenzen (78228-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / ethane-1,2-diol; pyridine

2: 35 percent / 30percent H₂O₂ / acetic acid

With dihydrogen peroxide; In pyridine; ethylene glycol; acetic acid;

DOI:10.1016/S0022-1139(00)81286-5

Reference yield:

morpholine (110-91-8,99108-56-2) + 4-fluoro-2-(methylsulfonyl)-1-nitrobenzen (78228-02-1) → C11H14N2O5S (1395172-28-7)

Guidance literature:

at 80 ℃; Neat (no solvent);

DOI:10.1016/j.bmcl.2012.04.131

upstream raw materials:

2,4-Difluoronitrobenzene

Downstream raw materials:

C₁₁H₁₄N₂O₅S