8-iodo-1-octanol

Base Information

• Chemical Name: 8-iodo-1-octanol
• CAS No.: 79918-35-7
• Molecular Formula: C8H17IO
• Molecular Weight: 256.127
• Mol file: 79918-35-7.mol

Synonyms:8-iodo-1-octanol

Chemical Property of 8-iodo-1-octanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.75430

Purity/Quality:

98% ^*data from raw suppliers

8-Iodooctan-1-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-iodo-1-octanol

There total 1 articles about 8-iodo-1-octanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

1,8-Octanediol (629-41-4) → 1,8-diiodooctane (24772-63-2) + 8-iodo-1-octanol (79918-35-7)

Guidance literature:

With 2,2,4-trimethylpentane; hydrogen iodide; for 4h; Heating;

DOI:10.1021/jo00342a039

Reference yield: 93.0%

2,6-dibromo-4-tert-butylphenol (98-22-6) + 8-iodo-1-octanol (79918-35-7) → C24H42Br2O2Si

Guidance literature:

With potassium carbonate; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201501507

Reference yield:

8-iodo-1-octanol (79918-35-7) → 7-(5-oxo-1-cyclopenten-1-yl)heptanoic acid (5239-43-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 75 percent / amberlyst H-15, H⁺ form / CH₂Cl₂ / 3 h / Ambient temperature

2: 85 percent / benzene / 6 h / Heating

3: 1.) n-butyllithium, 2.) HMPTA / 1.) THF, 0 deg C, 30 min, 2.) -78 deg C, 3 h

4: 85 percent / aluminium amalgam / tetrahydrofuran; H₂O / 3 h / Heating

5: 67 percent / pyridinium chlorochromate on alumina / CH₂Cl₂ / 3 h / Ambient temperature

6: 60 percent / 1percent aq NaOH / 1 h / 70 °C

7: 70 percent / 8 N chromic acid / acetone

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; aluminium amalgam; pyridiniumchlorochromate on aluminumoxide; Amberlyst H-15; hydrogen cation; chromic acid; In tetrahydrofuran; dichloromethane; water; acetone; benzene;

DOI:10.1021/jo00342a039

upstream raw materials:

1,8-Octanediol

Downstream raw materials:

oxacyclododecan-2-one

octyl acrylate

7-(5-oxo-1-cyclopenten-1-yl)heptanoic acid

8-<(tetrahydropyran-2-yl)oxy>octane benzenesulfinate

Refernces