GUANIDINE

Base Information

• Chemical Name: GUANIDINE
• CAS No.: 90332-86-8
• Molecular Formula: CH₇N₃*CO₃
• Molecular Weight: 121.096
• Mol file: 90332-86-8.mol

Synonyms:GUANIDINE;iminourea;aminoformamidine;aminomethanamidine

Chemical Property of GUANIDINE

Chemical Property:

• PKA: 13.6(at 25℃)
• PSA: 57.53000
• LogP: 0.22240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Two derivatives of guanidine, dodine (27) and iminoctadine (28), are being used as agricultural fungicides . The former was reported in 1957 (28), whereas the latter is new as a member of the multisite inhibitor group of fungicides. Both have one or two guanidine group(s) connected to a long chain alkyl or iminodi( polymethylene) group and seem to belong to a kind of cationic surface active agent.
• Biological Functions: Guanidine hydrochloride is the drug of choice in the management of patients with myasthenic syndrome and may be of use in the treatment of botulinum intoxication. Its ability to enhance transmitter release may involve a block of K+ channels and prolongation of the nerve action potential.

Technology Process of GUANIDINE

There total 18 articles about GUANIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitrocarbamoyl-guanidine (28787-21-5) + N-butylamine (109-73-9,85404-21-3) → N,N'-di-n-butylurea (1792-17-2) + N-butyl-N'-guanyl-urea (44987-80-6) + diguanidine carbonate (593-85-1,90332-86-8,3425-08-9)

Guidance literature:

DOI:10.1002/hlca.19520350533

Reference yield:

guanidine nitrate (113-00-8) → diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + urea (57-13-6)

Guidance literature:

In not given; byproducts: (NH4)2CO3, ammonium cyanate, guanidinium cyanate; heating with reflux; 3 h; 0.125 N soln. of guanidine; Kinetics;

DOI:10.1039/JR9262901213

Reference yield:

N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → diguanidine carbonate (593-85-1,90332-86-8,3425-08-9)

Guidance literature:

With ammonia; water;

upstream raw materials:

guanidine nitrate

nitrocarbamoyl-guanidine

N-butylamine

N-Cyanoguanidine

Downstream raw materials:

N,N'-dibenzoylurea

1-phenyl-3-guanylthiourea

1-p-chlorophenyl-3-formamidinothiocarbamide

1-cyclohexylguanidine