5-(4-CHLOROPHENYL)NICOTINALDEHYDE

Base Information

• Chemical Name: 5-(4-CHLOROPHENYL)NICOTINALDEHYDE
• CAS No.: 887973-65-1
• Molecular Formula: C₁₂H₈ClNO
• Molecular Weight: 217.655
• Hs Code.: 2933399090
• Mol file: 887973-65-1.mol

Synonyms:5-(4-CHLOROPHENYL)NICOTINALDEHYDE;5-(4-CHLOROPHENYL)PYRIDINE-3-CARBALDEHYDE

Chemical Property of 5-(4-CHLOROPHENYL)NICOTINALDEHYDE

Chemical Property:

• PSA: 29.96000
• LogP: 3.21450
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Chlorophenyl)nicotinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-CHLOROPHENYL)NICOTINALDEHYDE

There total 3 articles about 5-(4-CHLOROPHENYL)NICOTINALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C14H12ClNO2 (1258269-08-7) → C12H8ClNO (887973-65-1)

Guidance literature:

With diisobutylaluminium hydride;

DOI:10.1016/j.bmcl.2013.01.066

Reference yield:

4-Chlorophenylboronic acid (1679-18-1) → C12H8ClNO (887973-65-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1111/cbdd.12881

Reference yield:

ethyl 5-bromo-3-pyridinecarboxylate (20986-40-7) + 4-Chlorophenylboronic acid (1679-18-1) → C12H8ClNO (887973-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate

2: diisobutylaluminium hydride

With bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride; sodium carbonate;

DOI:10.1016/j.bmcl.2013.01.066

upstream raw materials:

ethyl 5-bromo-3-pyridinecarboxylate

4-Chlorophenylboronic acid

C₁₄H₁₂ClNO₂