3-fluoro-5-iodophenol

Base Information

• Chemical Name: 3-fluoro-5-iodophenol
• CAS No.: 939771-60-5
• Molecular Formula: C6H4FIO
• Molecular Weight: 238
• Mol file: 939771-60-5.mol

Synonyms:3-fluoro-5-iodophenol

Chemical Property of 3-fluoro-5-iodophenol

Chemical Property:

• PSA: 20.23000
• LogP: 2.13590
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-5-iodophenol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-5-iodophenol

There total 5 articles about 3-fluoro-5-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-fluoro-3-iodo-5-methoxybenzene (1167056-58-7) → 3-fluoro-5-iodophenol (939771-60-5)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 13h; Inert atmosphere;

DOI:10.1021/ja2058583

Reference yield:

3-fluoro-5-methoxyphenylamine (2339-58-4) → 3-fluoro-5-iodophenol (939771-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C

1.2: 1 h / Cooling with ice; Reflux

2.1: boron tribromide / dichloromethane / 13 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; boron tribromide; sodium nitrite; In dichloromethane; water;

DOI:10.1021/ja2058583

Reference yield:

1,3-difluoro-5-nitrobenzene (2265-94-3) → 3-fluoro-5-iodophenol (939771-60-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

2.1: iron; ammonium chloride / ethanol; water / 6 h / 75 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C

3.2: 1 h / Cooling with ice; Reflux

4.1: boron tribromide / dichloromethane / 13 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; boron tribromide; iron; sodium hydride; ammonium chloride; sodium nitrite; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water;

DOI:10.1021/ja2058583

upstream raw materials:

1-fluoro-3-iodo-5-methoxybenzene

3-fluoro-5-methoxyphenylamine

1,3-difluoro-5-nitrobenzene

1-fluoro-3-methoxy-5-nitrobenzene

Downstream raw materials:

C₁₆H₁₀FN₃O

C₂₃H₁₆FN₅O

C₉H₆FNO

4-chloro-1-(3-fluoro-5-iodophenoxy)-2-methoxybenzene