3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Base Information

Chemical Name:3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS No.:1159522-34-5
Molecular Formula:C10H11N5
Molecular Weight:201.22784
Hs Code.:
Mol file:1159522-34-5.mol

Synonyms:3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;5,6,7,8-tetrahydro-3-(2-pyridinyl)-1,2,4-Triazolo[4,3-a]pyrazine

Suppliers and Price of 3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Chemical Property:

Boiling Point:460.3±55.0 °C(Predicted)
PKA:6.40±0.20(Predicted)
PSA：55.63000
Density:1.46±0.1 g/cm3(Predicted)
LogP:0.77210

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of 3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

There total 2 articles about 3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1254073-77-2
tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

: 1159522-34-5
3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:: tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

With water; for 0.5h; Inert atmosphere;
DOI:10.1021/jm5017413

Reference yield:

: 1452-63-7
picolinic acid hydrazide

: 1159522-34-5
3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / Reflux; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

With trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm5017413

Reference yield: 73.0%

: 1159522-34-5
3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

: 393-52-2
2-Fluorobenzoyl chloride

: (2-fluorophenyl)(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: 3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

2-Fluorobenzoyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm5017413