tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate
CAS No.:1254073-77-2
Molecular Formula:C₁₅H₁₉N₅O₂
Molecular Weight:301.348
Hs Code.:

Synonyms:tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

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Chemical Property of tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

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Technology Process of tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

There total 2 articles about tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76003-29-7
4-(t-butyloxycarbonyl)piperazin-2-one

: 1254073-77-2
tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C / Inert atmosphere

2: ethanol / Reflux; Inert atmosphere

In ethanol; dichloromethane;
DOI:10.1021/jm5017413

Reference yield:

: 723286-80-4
3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

: 17997-47-6
2-tri-n-butylstannylpyridine

: 1254073-77-2
tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 130 ℃; Microwave irradiation; Inert atmosphere;

Reference yield: 46.0%

: 1254073-77-2
tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

: 1159522-34-5
3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:: tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

With water; for 0.5h; Inert atmosphere;
DOI:10.1021/jm5017413