[1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

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Chemical Name:[1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone
CAS No.:1338372-21-6
Molecular Formula:C₂₃H₁₉N₅O
Molecular Weight:381.437
Hs Code.:

Synonyms:[1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

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Chemical Property of [1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

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Technology Process of [1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

There total 4 articles about [1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1159522-34-5
3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

: 14002-51-8
4-biphenyl-carboxylic acid chloride

: 1338372-21-6
[1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: 3-(2-pyridyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

4-biphenyl-carboxylic acid chloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm5017413

Reference yield:

: 1254073-77-2
tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylate

: 1338372-21-6
[1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm5017413

Reference yield:

: 1452-63-7
picolinic acid hydrazide

: 1338372-21-6
[1,1′-biphenyl]-4-yl(3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / Reflux; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 0.17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm5017413