6-Amino-5-bromopicolinic acid

Base Information

• Chemical Name: 6-Amino-5-bromopicolinic acid
• CAS No.: 1221629-04-4
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20704811
• Wikidata: Q82637373
• Mol file: 1221629-04-4.mol

Synonyms:6-Amino-5-bromopicolinic acid;1221629-04-4;6-Amino-5-bromopyridine-2-carboxylic acid;6-Amino-5-bromopicolinicacid;DTXSID20704811;MFCD08062949;AKOS022176091;CS-0372586;EN300-142189;F31272;Z1269123358

Chemical Property of 6-Amino-5-bromopicolinic acid

Chemical Property:

• PSA: 76.21000
• LogP: 1.70570
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 215.95344
• Heavy Atom Count: 11
• Complexity: 165

Purity/Quality:

95+% ^*data from raw suppliers

6-Amino-5-bromopyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1Br)N)C(=O)O

Technology Process of 6-Amino-5-bromopicolinic acid

There total 5 articles about 6-Amino-5-bromopicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

N-(3-bromo-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (135995-44-7) → 6-amino-5-bromopyridine 2-carboxylic acid (1221629-04-4) + C11H13BrN2O3

Guidance literature:

With potassium permanganate; In water; Reflux;

DOI:10.1021/op900092h

Reference yield:

2-amino-3-bromo-6-methyl-pyridine (126325-46-0) → 6-amino-5-bromopyridine 2-carboxylic acid (1221629-04-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 18 h / 50 °C

2: sodium permanganate; potassium dihydrogenphosphate / water / 80 - 85 °C

3: sulfuric acid / methanol

With potassium dihydrogenphosphate; sodium permanganate; sulfuric acid; In 1,4-dioxane; methanol; water;

DOI:10.1021/acsmedchemlett.5b00059

Reference yield:

N-(3-bromo-6-methylpyridin-2-yl)acetamide (875051-78-8) → 6-amino-5-bromopyridine 2-carboxylic acid (1221629-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium permanganate; potassium dihydrogenphosphate / water / 80 - 85 °C

2: sulfuric acid / methanol

With potassium dihydrogenphosphate; sodium permanganate; sulfuric acid; In methanol; water;

DOI:10.1021/acsmedchemlett.5b00059

upstream raw materials:

methanol

6-acetamido-5-bromopyridine 2-carboxylic acid

N-(3-bromo-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

2-amino-3-bromo-6-methyl-pyridine