126325-46-0Relevant articles and documents
Preparation process of 2-amino-3-bromo-6-methylpyridine
-
Paragraph 0024-0032, (2019/10/01)
The invention discloses a preparation process of 2-amino-3-bromo-6-methylpyridine. The preparation process comprises the following steps: adding 2-amino-6-methylpyridine into a solvent, adding hydrogen peroxide in the presence of sulfuric acid, uniformly carrying out stirring, then adding bromine, and carrying out stirring for a reaction to obtain an intermediate 2-amino-3,5-dibromo-6-methylpyridine; and adding the 2-amino-3,5-dibromo-6-methylpyridine into a solvent, carrying out stirring, adding a lithiation reagent, and carrying out a reaction to obtain 2-amino-3-bromo-6-methylpyridine. Theinvention provides a preparation process of 2-amino-3-bromo-6-methylpyridine, the 2-amino-3-bromo-6-methylpyridine is prepared through a two-step reaction, and the preparation method is simple. Through addition of the hydrogen peroxide, the utilization rate of the bromine is increased from 50% to close to 100%, so that the usage amount of the bromine is greatly reduced, the yield of the product isincreased, emission of three wastes (waste gas, waste water, and industrial residues) is reduced, environment friendliness is achieved, and cost is saved.
Bromination of Pyridines. II. Bromination of Aminopicolines
Dunn, A. D.,Currie, A.,Hayes, L. E.
, p. 369 - 374 (2007/10/02)
The bromination of all ten possible aminopicolines 1-10 was investigated.In general, the major brominated product was that corresponding to electrophilic attack at the sites para or ortho to the amino group.