Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate

Base Information

• Chemical Name: Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate
• CAS No.: 917755-77-2
• Molecular Formula: C20H28FNO4
• Molecular Weight: 365.445
• European Community (EC) Number: 693-810-4
• DSSTox Substance ID: DTXSID60584851
• Wikidata: Q82476590
• Mol file: 917755-77-2.mol

Synonyms:917755-77-2;Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate;1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROBENZYL)PIPERIDINE-1,4-DICARBOXYLATE;1-tert-butyl 4-ethyl 4-(4-fluorobenzyl)-piperidine-1,4-dicarboxylate;1-O-tert-butyl 4-O-ethyl 4-[(4-fluorophenyl)methyl]piperidine-1,4-dicarboxylate;1-tert-Butyl 4-ethyl 4-[(4-fluorophenyl)methyl]piperidine-1,4-dicarboxylate;C20H28FNO4;SCHEMBL3355644;DTXSID60584851;KIIYXHXWARGQKK-UHFFFAOYSA-N;MFCD09038430;AKOS025312364;AB92383;CS-W001683;s11253;WS-02202;1-Boc-4-ethyl 4-(4-fluorobenzyl)piperidine-4-carboxylate;Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate, 97%;1-t-Butyl 4-ethyl 4-(4-fluorobenZyl)piperidine-1,4-dicarboxylate;1-TERT-BUTYL4-ETHYL4-(4-FLUOROBENZYL)PIPERIDINE-1,4-DICARBOXYLATE;4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Chemical Property of Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate

Chemical Property:

• Melting Point: 62-66 °C
• PSA: 55.84000
• LogP: 3.88650
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 365.20023654
• Heavy Atom Count: 26
• Complexity: 487

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-tert-Butyl4-Ethyl4-(4-fluorobenzyl)piperidine-1,4-dicarboxylate(withMethyesteranalog) 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1(CCN(CC1)C(=O)OC(C)(C)C)CC2=CC=C(C=C2)F

Technology Process of Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate

There total 1 articles about Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

4-Fluorobenzyl bromide (459-46-1) + 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → 4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (917755-77-2)

Guidance literature:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -40 ℃; for 1h;

4-Fluorobenzyl bromide; In tetrahydrofuran; at -78 ℃; for 2h; Product distribution / selectivity;

Reference yield: 97.7%

4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (917755-77-2) → 4-(4-fluoro-benzyl)-piperidine-4-carboxyl ic acid ethyl ester (934368-01-1)

Guidance literature:

4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In water;

Reference yield:

4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (917755-77-2) → tert-butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)piperidine-1-carboxylate (917755-78-3)

Guidance literature:

4-(4-Fluoro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 10 ℃;

With water; sodium hydroxide; In diethyl ether;

upstream raw materials:

4-Fluorobenzyl bromide

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Downstream raw materials:

4-(4-fluoro-benzyl)-piperidine-4-carboxyl ic acid ethyl ester

tert-butyl 4-(4-fluorobenzyl)-4-(hydroxymethyl)piperidine-1-carboxylate

1-tert-butoxycarbonyl-4-(4-fluoro-phenylmethyl)-piperidine-4-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 917755-77-2 ETHYL N-BOC-4-(4-FLUOROBENZYL)PIPERIDINE-4-CARBOXYLATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send