1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

Base Information

• Chemical Name: 1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine
• CAS No.: 1313738-72-5
• Molecular Formula: C13H9FIN3
• Molecular Weight: 353.137
• Hs Code.: 2933990090
• Mol file: 1313738-72-5.mol

Synonyms:1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine;1-[(2-fluorophenyl)methyl]-3-iodo-1H-pyrazolo[3,4-b]pyridine

Chemical Property of 1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

• Boiling Point: 451.1±40.0 °C(Predicted)
• PKA: 2.11±0.30(Predicted)
• PSA: 30.71000
• Density: 1.79±0.1 g/cm3(Predicted)
• LogP: 3.22330

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

There total 2 articles about 1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1313738-72-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 71.6%

o-fluorobenzyl bromide (446-48-0) + 3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1313738-72-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Concentration; Solvent;

Reference yield: 63.7%

zinc(II) cyanide (557-21-1) + 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1313738-72-5) → 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile (256376-65-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 120 ℃; for 13h; Concentration; Temperature;

upstream raw materials:

o-fluorobenzyl bromide

3-iodo-1H-pyrazolo[3,4-b]pyridine

Downstream raw materials:

6-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyridine-2,3-diamine

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidine-4,5-diamine

Ethyl 5,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4-carboxylate

methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate