methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate

Base Information

• Chemical Name: methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate
• CAS No.: 1361570-64-0
• Molecular Formula: CH₂O₂*C₂₀H₁₈FN₇O₂
• Molecular Weight: 453.433
• Mol file: 1361570-64-0.mol

Synonyms:methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate

Chemical Property of methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate

There total 4 articles about methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

formic acid (64-18-6) + 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidine-4,5-diamine (1361570-49-1) + methyl chloroformate (79-22-1) → methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate (1361570-64-0)

Guidance literature:

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidine-4,5-diamine; methyl chloroformate; With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

formic acid; In water; acetonitrile;

Reference yield:

1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1313738-72-5) → methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate (1361570-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(tri-n-butyltin); bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux

2: pyridine; palladium; hydrogen

3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; hydrogen; bis(tri-n-butyltin); palladium; In 1,4-dioxane; dichloromethane;

Reference yield:

4-Amino-5-nitro-6-methyl-2-chloropyrimidine (5453-06-5) → methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate (1361570-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(tri-n-butyltin); bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux

2: pyridine; palladium; hydrogen

3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; hydrogen; bis(tri-n-butyltin); palladium; In 1,4-dioxane; dichloromethane;

upstream raw materials:

formic acid

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidine-4,5-diamine

methyl chloroformate

1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

Downstream raw materials:

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methyl-7,9-dihydro-8H-purin-8-one