4-FLUORO-2-METHYLPHENOXY ACETIC ACID

Base Information

• Chemical Name: 4-FLUORO-2-METHYLPHENOXY ACETIC ACID
• CAS No.: 451-88-7
• Molecular Formula: C9H9FO3
• Molecular Weight: 184.1643632
• Mol file: 451-88-7.mol

Synonyms:4-FLUORO-2-METHYLPHENOXY ACETIC ACID;2-(4-Fluoro-2-Methylphenoxy)-acetic acid

Chemical Property of 4-FLUORO-2-METHYLPHENOXY ACETIC ACID

Chemical Property:

• PSA: 46.53000
• LogP: 1.59750

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Fluoro-2-methylphenoxy)aceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-2-METHYLPHENOXY ACETIC ACID

There total 4 articles about 4-FLUORO-2-METHYLPHENOXY ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-2-methylphenol (452-72-2) + chloroacetic acid (79-11-8) → 2-(4-fluoro-2-methylphenoxy)acetic acid (451-88-7)

Guidance literature:

With sodium hydroxide; water;

DOI:10.1021/ja01195a604

Reference yield:

4-fluoro-2-methylphenol (452-72-2) + ethyl bromoacetate (105-36-2) → 2-(4-fluoro-2-methylphenoxy)acetic acid (451-88-7)

Guidance literature:

4-fluoro-2-methylphenol; ethyl bromoacetate; With potassium carbonate; In dimethyl sulfoxide; at 50 ℃; for 6h;

With water; sodium hydroxide; In acetone; at 50 ℃; for 3h;

With hydrogenchloride; In water; at 25 ℃; pH=1 - 2;

DOI:10.1021/acs.jafc.6b04110

Reference yield:

4-fluoro-2-methylphenol (452-72-2) → 2-(4-fluoro-2-methylphenoxy)acetic acid (451-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

1.2: 12 h / 50 °C

2.1: lithium hydroxide / methanol; water / 12 h / 50 °C

With potassium carbonate; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jafc.9b03109

upstream raw materials:

4-fluoro-2-methylphenol

chloroacetic acid

ethyl bromoacetate