(3R)-1-Methyl-3-PyrrolidinaMine hydrochloride

Base Information

• Chemical Name: (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride
• CAS No.: 403712-80-1
• Molecular Formula: C₅H₁₂N₂*ClH
• Molecular Weight: 136.625
• Mol file: 403712-80-1.mol

Synonyms:(3R)-1-Methyl-3-PyrrolidinaMine hydrochloride;R-1-Methylpyrrolidin-3-aMine.2HCl;(R)-1-methylpyrrolidin-3-amine dihydrochloride;R-1-Methyl-pyrrolidin-3-ylamine dihydrochloride

Chemical Property of (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99%, ^*data from raw suppliers

R-1-Methyl-pyrrolidin-3-ylaminedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride

There total 6 articles about (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-N-tert-butoxycarbonyl-3-(R)-amino-1-methylpyrrolidine (346691-01-8) → 1-methyl-3-(R)-aminopyrrolidine dihydrochloride (1209287-84-2,403712-80-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.333333h;

DOI:10.1021/jm010329a

Reference yield:

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate (852874-60-3) → (S)-1-methylpyrrolidine-3-amine hydrochloride (852874-61-4,1209287-84-2,403712-80-1)

Guidance literature:

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; diethyl ether;

Reference yield:

tert-butyl (1-methylpyrrolidin-3-yl)carbamate (748184-01-2) → 1-methylpyrrolidin-3-ylamino hydrochloride (1209287-84-2,403712-80-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.75h;

upstream raw materials:

3-N-tert-butoxycarbonyl-3-(R)-amino-1-methylpyrrolidine

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate

tert-butyl (1-methylpyrrolidin-3-yl)carbamate

Downstream raw materials:

2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((S)-1-methylpyrrolidin-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide

2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((R)-1-methylpyrrolidin-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide

4-amino-2,5-difluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide

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