1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE

Base Information

• Chemical Name: 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE
• CAS No.: 358780-14-0
• Molecular Formula: C8H6F3NO
• Molecular Weight: 189.1345496
• Hs Code.: 2933399090
• Mol file: 358780-14-0.mol

Synonyms:1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;ETHANONE, 1-[6-(TRIFLUOROMETHYL)-3-PYRIDINYL]-;1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one;5-Acetyl-2-(trifluoromethyl)pyridine;1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone;[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE

Chemical Property of 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE

Chemical Property:

• Boiling Point: 233.7±40.0 °C(Predicted)
• PKA: -1.24±0.22(Predicted)
• PSA: 29.96000
• Density: 1.280±0.06 g/cm3(Predicted)
• LogP: 2.30300
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(6-(trifluoromethyl)pyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone can be used as novel GPR119 agonists.

Technology Process of 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE

There total 16 articles about 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl magnesium iodide (917-64-6) + N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide (416852-53-4) → 1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one (358780-14-0)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield: 98.0%

N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide (416852-53-4) + methylmagnesium bromide (75-16-1) → 1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one (358780-14-0)

Guidance literature:

In tetrahydrofuran; toluene; at 0 ℃; for 1h;

Reference yield: 79.0%

6-(trifluoromethyl)nicotinoyl chloride (358780-13-9) + malonic acid dimethyl ester (108-59-8) → 1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one (358780-14-0)

Guidance literature:

malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; for 2.5h; light cooling;

6-(trifluoromethyl)nicotinoyl chloride; In toluene; for 2h; Cooling;

With hydrogenchloride; water; more than 3 stages;

upstream raw materials:

6-(trifluoromethyl)nicotinoyl chloride

methylmagnesium bromide

6-(trifluoromethyl)nicotinonitrile

N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide

Downstream raw materials:

3-dimethylamino-1-(6-trifluoromethylpyridin-3-yl)-propenone

2-(3-bromophenyl)-4-(trifluoromethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)pyrimidine

(±)-1-[(6-trifluoromethyl)pyridine-3-yl]ethan-1-amine