1,1-Cyclopentanediacetic acid dimethyl ester

Base Information

• Chemical Name: 1,1-Cyclopentanediacetic acid dimethyl ester
• CAS No.: 70197-60-3
• Molecular Formula: C₁₁H₁₈O₄
• Molecular Weight: 214.262
• Mol file: 70197-60-3.mol

Synonyms:1,1-Cyclopentanediacetic acid dimethyl ester

Chemical Property of 1,1-Cyclopentanediacetic acid dimethyl ester

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Boiling Point: 259.538°C at 760 mmHg
• Flash Point: 118.808°C
• PSA: 52.60000
• Density: 1.059g/cm³
• LogP: 1.67300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-Cyclopentanediacetic acid dimethyl ester

There total 2 articles about 1,1-Cyclopentanediacetic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 1,1-cyclopentanediacetic acid (16713-66-9) → dimethyl 2,2'-(cyclopentane-1,1-diyl)diacetate (70197-60-3)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jo01328a042

Reference yield:

→ dimethyl 2,2'-(cyclopentane-1,1-diyl)diacetate (70197-60-3)

Guidance literature:

Entspr. Disaeure, Me., H2SO4;

DOI:10.1021/je60048a031

Reference yield:

dimethyl 2,2'-(cyclopentane-1,1-diyl)diacetate (70197-60-3) → 3-oxospiro[4.4]nonan-2-yl 4-methylbenzenesulfonate

Guidance literature:

Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; sodium / toluene / 20 °C / Reflux

2: pyridine / 48 h / 0 °C / Darkness

With pyridine; chloro-trimethyl-silane; sodium; In toluene; 1: |Acyloin Condensation;

DOI:10.1021/jacs.5b13041

upstream raw materials:

methanol

1,1-cyclopentanediacetic acid