2-(3-Methoxyphenyl)aniline

Base Information

• Chemical Name: 2-(3-Methoxyphenyl)aniline
• CAS No.: 38089-02-0
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Hs Code.: 2922299090
• European Community (EC) Number: 673-285-8
• DSSTox Substance ID: DTXSID50374844
• Nikkaji Number: J2.733.272B
• Wikidata: Q82163413
• Mol file: 38089-02-0.mol

Synonyms:38089-02-0;2-(3-methoxyphenyl)aniline;3'-methoxy[1,1'-biphenyl]-2-amine;(3'-methoxybiphenyl-2-yl)amine;3'-methoxybiphenyl-2-ylamine;3'-Methoxybiphenyl-2-amine;3'-Methoxy-[1,1'-biphenyl]-2-amine;3'-Methoxybiphenyl-2-ylamine, HCl;SBB007488;SCHEMBL396757;DTXSID50374844;JMQIDJIQNGOLKM-UHFFFAOYSA-N;MFCD03424651;AKOS000314401;3'-Methoxy-1,1'-biphenyl-2-ylamine;BB 0222440;CS-0216617;EN300-5257320

Chemical Property of 2-(3-Methoxyphenyl)aniline

Chemical Property:

• Boiling Point: 337.5±17.0 °C(Predicted)
• PKA: 3.66±0.10(Predicted)
• Flash Point: 164oC
• PSA: 35.25000
• Density: 1.100±0.06 g/cm3(Predicted)
• LogP: 3.52560
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.099714038
• Heavy Atom Count: 15
• Complexity: 195

Purity/Quality:

98% ^*data from raw suppliers

3'-Methoxy-[1,1'-biphenyl]-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2=CC=CC=C2N

Technology Process of 2-(3-Methoxyphenyl)aniline

There total 11 articles about 2-(3-Methoxyphenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) + 2-bromoaniline (615-36-1) → 3'-methoxy-[1,1'-biphenyl]-2-amine (38089-02-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; at 80 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201604421

Reference yield: 89.0%

2-iodophenylamine (615-43-0) + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 3'-methoxy-[1,1'-biphenyl]-2-amine (38089-02-0)

Guidance literature:

2-iodophenylamine; 3-methoxyphenylboronic acid; With potassium carbonate; In 1,2-dimethoxyethane; water; at 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

With bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201510533

Reference yield: 84.0%

→ 3'-methoxy-[1,1'-biphenyl]-2-amine (38089-02-0)

Guidance literature:

upstream raw materials:

2-(3-Methoxyphenyl)nitrobenzene

2-iodophenylamine

methoxybenzene

3-methoxyphenyl bromide

Downstream raw materials:

3'-methoxy-1,1'-biphenyl-2-ol

N-(Phenylmethylene)-(3-methoxy-1,1'-biphenyl)-2-amine

9-methoxy-6-phenylphenanthridine

7-Methoxy-6-phenylphenanthridine