2-broMo-6-fluoro-3-Methylbenzoic acid

Base Information

• Chemical Name: 2-broMo-6-fluoro-3-Methylbenzoic acid
• CAS No.: 1359857-60-5
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Hs Code.: 2916399090
• Mol file: 1359857-60-5.mol

Synonyms:2-broMo-6-fluoro-3-Methylbenzoic acid;6-Bromo-2-fluoro-5-methylbenzoic acid

Chemical Property of 2-broMo-6-fluoro-3-Methylbenzoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.59480
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-6-fluoro-3-methylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-broMo-6-fluoro-3-Methylbenzoic acid

There total 3 articles about 2-broMo-6-fluoro-3-Methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-6-fluoro-3-methylbenzaldehyde (154650-16-5) → 2-bromo-6-fluoro-3-methylbenzoic acid (1359857-60-5)

Guidance literature:

2-bromo-6-fluoro-3-methylbenzaldehyde; With sodium chlorite; 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; In water; tert-butyl alcohol; at 20 ℃; for 0.5h;

With hydrogenchloride; In water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield: 85.0%

2-bromo-4-fluorotoluene (1422-53-3) + carbon dioxide (124-38-9,18923-20-1) → 2-bromo-6-fluoro-3-methylbenzoic acid (1359857-60-5)

Guidance literature:

2-bromo-4-fluorotoluene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; Cooling with ice;

carbon dioxide; In tetrahydrofuran; for 0.333333h; Cooling with ice;

Reference yield:

2-bromo-4-fluorotoluene (1422-53-3) → 2-bromo-6-fluoro-3-methylbenzoic acid (1359857-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 2.17 h / -78 °C

1.2: 0.33 h / -78 °C

2.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C

With sodium chlorite; n-butyllithium; 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; diisopropylamine; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2011.12.096

upstream raw materials:

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-4-fluorotoluene

carbon dioxide

Downstream raw materials:

C₁₂H₁₃BrO₅

C₁₈H₂₅BO₇

C₁₇H₂₂BFO₆

C₉H₆Br₃FO₂

Refernces

• 1、 -. "ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES". Paragraph 0167. . Retrieved 2019/02/25.
• 2、 Zhang, Yong-Kang,Plattner, Jacob J.,Freund, Yvonne R.,Easom, Eric E.,Zhou, Yasheen,Ye, Long,Zhou, Huchen,Waterson, David,Gamo, Francisco-Javier,Sanz, Laura M.,Ge, Min,Li, Zhiya,Li, Lingchao,Wang, Hailong,Cui, Han. "Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles". experimental part. p. 1299 - 1307. Retrieved 2012/03/26.