2-BROMO-4'-CYANOBENZOPHENONE

Base Information

• Chemical Name: 2-BROMO-4'-CYANOBENZOPHENONE
• CAS No.: 746651-77-4
• Molecular Formula: C14H8BrNO
• Molecular Weight: 286.12
• Hs Code.: 2926909090
• Mol file: 746651-77-4.mol

Synonyms:2-BROMO-4'-CYANOBENZOPHENONE

Chemical Property of 2-BROMO-4'-CYANOBENZOPHENONE

Chemical Property:

• Vapor Pressure: 2.11E-07mmHg at 25°C
• Boiling Point: 424.2°C at 760 mmHg
• Flash Point: 210.3°C
• PSA: 40.86000
• Density: 1.53g/cm³
• LogP: 3.55178

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4'-cyanobenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4'-CYANOBENZOPHENONE

There total 3 articles about 2-BROMO-4'-CYANOBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-Bromo-2-iodobenzene (583-55-1) + carbon monoxide (201230-82-2) + 4-cyanophenylboronic acid (126747-14-6) → 4-(2-bromobenzoyl)benzonitrile (746651-77-4)

Guidance literature:

With potassium carbonate; palladium dichloride; at 80 ℃; for 20h;

DOI:10.1039/d0ob00044b

Reference yield:

C14H10BrNO (1334402-91-3) → 4-(2-bromobenzoyl)benzonitrile (746651-77-4)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

DOI:10.1021/ol2023505

Reference yield:

4-bromobenzenecarbonitrile (623-00-7) + ortho-bromobenzaldehyde (6630-33-7) → 4-(2-bromobenzoyl)benzonitrile (746651-77-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 0 °C

1.2: 0 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; TurboGrignard; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol2023505

upstream raw materials:

C₁₄H₁₀BrNO

4-bromobenzenecarbonitrile

ortho-bromobenzaldehyde

1-Bromo-2-iodobenzene

Refernces

• 1、 Lockner, Jonathan W.,Dixon, Darryl D.,Risgaard, Rune,Baran, Phil S.. "Practical radical cyclizations with arylboronic acids and trifluoroborates". supporting information; experimental part. p. 5628 - 5631. Retrieved 2011/12/03.