4,5-Diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

Base Information

• Chemical Name: 4,5-Diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole
• CAS No.: 216314-79-3
• Molecular Formula: C9H16I2N2OSi
• Molecular Weight: 450.133
• Mol file: 216314-79-3.mol

Synonyms:4,5-Diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole;4,5-diiodo-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazole

Chemical Property of 4,5-Diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

Chemical Property:

• PSA: 27.05000
• LogP: 3.40460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-Diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

There total 2 articles about 4,5-Diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,5-diiodo-1H-imidazole (15813-09-9) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 4,5-diiodo-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazole (216314-79-3)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide);

Reference yield: 43.0%

2,4,5-triiodoimidazole (1746-25-4) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 4,5-diiodo-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazole (216314-79-3)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 41.0%

3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester (863579-14-0) + 4,5-diiodo-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazole (216314-79-3) → 3-cyclohexyl-2-[4-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-5-yl]-1H-indole-6-carboxylic acid methyl ester (877277-80-0)

Guidance literature:

With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 70 ℃; for 24h;

upstream raw materials:

2,4,5-triiodoimidazole

(2-trimethylethylsilylethoxy)methyl chloride

4,5-diiodo-1H-imidazole

Downstream raw materials:

3-cyclohexyl-2-[4-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-5-yl]-1H-indole-6-carboxylic acid methyl ester

3-cyclohexyl-2-[4-ethenyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-5-yl]-1H-indole-6-carboxylic acid methyl ester

3-cyclohexyl-2-[4-ethenyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-5-yl]-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

12-cyclohexyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-imidazo[4',5':3,4]azepino[1,2-a]indole-9-carboxylic acid methyl ester