4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine hydrochloride, 1-(Piperidin-4-yl)-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride

Base Information

• Chemical Name: 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine hydrochloride, 1-(Piperidin-4-yl)-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride
• CAS No.: 1175273-62-7
• Molecular Formula: C14H25BClN3O2
• Molecular Weight: 313.6312
• Hs Code.: 2933399990
• Mol file: 1175273-62-7.mol

Synonyms:1-(Piperidin-4-yl)-1H-pyrazole-4-boronic acid, pinacol ester hydrochloride;4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine hydrochloride, 1-(Piperidin-4-yl)-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride;4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride

Chemical Property of 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine hydrochloride, 1-(Piperidin-4-yl)-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-PIPERIDINYL)-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER HYDROCHLORIDE 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine hydrochloride, 1-(Piperidin-4-yl)-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride

There total 4 articles about 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine hydrochloride, 1-(Piperidin-4-yl)-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (877399-74-1) → 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride (1175273-62-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 35 ℃; for 3h;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride (1175273-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 35 °C

With hydrogenchloride; dmap; caesium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate (141699-59-4) → 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride (1175273-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 35 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

pyrazole-4-boronic acid pinacol ester

Downstream raw materials:

1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine

Refernces

• 1、 -. "SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS". Paragraph 0313; 0314. . Retrieved 2014/05/08.
• 2、 -. "FUSED BICYCLIC KINASE INHIBITORS". Page/Page column 41. . Retrieved 2011/12/02.