4,4,5,5-TetraMethyl-2-(3-(trifluoroMethyl)benzyl)-1,3,2-dioxaborolane

Base Information

• Chemical Name: 4,4,5,5-TetraMethyl-2-(3-(trifluoroMethyl)benzyl)-1,3,2-dioxaborolane
• CAS No.: 1190235-39-2
• Molecular Formula: C14H18BF3O2
• Molecular Weight: 286.102
• Hs Code.: 2934999090
• Mol file: 1190235-39-2.mol

Synonyms:4,4,5,5-TetraMethyl-2-(3-(trifluoroMethyl)benzyl)-1,3,2-dioxaborolane

Chemical Property of 4,4,5,5-TetraMethyl-2-(3-(trifluoroMethyl)benzyl)-1,3,2-dioxaborolane

Chemical Property:

• Boiling Point: 278.0±40.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 4.14570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,4,5,5-Tetramethyl-2-(3-(trifluoromethyl)benzyl)-1,3,2-Dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4,5,5-TetraMethyl-2-(3-(trifluoroMethyl)benzyl)-1,3,2-dioxaborolane

There total 2 articles about 4,4,5,5-TetraMethyl-2-(3-(trifluoroMethyl)benzyl)-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-bromomethyl-3-trifluoromethylbenzene (402-23-3) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3,2-dioxaborolane (1190235-39-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 12h;

Reference yield: 72.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + (meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) + diazomethyl-trimethyl-silane (18107-18-1) → 4,4,5,5-tetramethyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3,2-dioxaborolane (1190235-39-2)

Guidance literature:

(meta-(trifluoromethyl)phenyl)boronic acid; diazomethyl-trimethyl-silane; In hexane; toluene; at 50 ℃; for 3h;

2,3-dimethyl-2,3-butane diol; With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; water; at 50 ℃; for 3h;

Reference yield: 99.0%

pinanediol (18680-27-8) + 4,4,5,5-tetramethyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3,2-dioxaborolane (1190235-39-2) → (3-trifluoromethylbenzyl)boronic acid (+)-pinane-2,3-diyl diester (1444010-73-4)

Guidance literature:

In diethyl ether; at 20 ℃; for 12h;

upstream raw materials:

1-bromomethyl-3-trifluoromethylbenzene

bis(pinacol)diborane

2,3-dimethyl-2,3-butane diol

(meta-(trifluoromethyl)phenyl)boronic acid

Downstream raw materials:

ethyl 1-({4-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylate

(1S)-1-chloro-2-(3-trifluoromethylphenyl)-ethylboronic acid (+)-pinane-2,3-diyl diester

[(1R)-1-[bis(trimethylsilyl)amino]-2-(3-trifluoromethylphenyl)ethyl]boronic acid (+)-pinane-2,3-diyl diester

[(1R)-1-amino-2-(3-trifluoromethylphenyl)ethyl]boronic acid (+)-pinane-2,3-diyl diester trifluroacetate

Refernces

• 1、 -. "ALPHA-AMINO BORONIC ACID DERIVATIVES, SELECTIVE IMMUNOPROTEASOME INHIBITORS". Page/Page column 47. . Retrieved 2013/07/05.